Loy R, Moore R Y
Anat Embryol (Berl). 1979;157(3):243-53. doi: 10.1007/BF00304992.
The noradrenergic (NA) innervation of the rat hippocampal formation arrives embryonically into a structure in which cytogenesis and cell migration are still active processes. At embryonic day 18 (E18) the first fluorescent axons appear in the septal end of CA3 at the boundary of the marginal zone and cortical plate, the future stratum lucidum. By birth axons invade the subiculum and also course along the septo-temporal axis in a longitudinal associational system in stratum moleculare of CA3. The innervation of the area dentata increases significantly by postnatal day four (P4). The innervation pattern throughout the dentate and Ammon's horn is fairly complete by P10. High affinity uptake of 3H-NA also matures embryonically and correlates postnatally with the extent of innervation estimated by fluorescence histochemistry. The levels of endogenous NA develop more slowly, showing only 60--80% of older adult values by P48. Compared to the maturation of other hippocampal afferents, the NA innervation is extremely precocious. It is localized in areas which could allow it to have significant trophic functions during early stages of histogenesis. In addition, its presence in the rapidly developing structure may contribute to its eventual distribution in a relatively less organized terminal pattern than that of the later-arriving entorhinal, commissural and septal afferents.
大鼠海马结构的去甲肾上腺素能（NA）神经支配在胚胎期就进入了一个细胞生成和细胞迁移仍在活跃进行的结构。在胚胎第18天（E18），第一批荧光轴突出现在CA3区的隔端，位于边缘区和皮质板（未来的透明层）的边界处。出生时，轴突侵入下托，并在CA3分子层的纵向联合系统中沿隔颞轴走行。齿状回区域的神经支配在出生后第4天（P4）显著增加。到出生后第10天（P10），整个齿状回和海马角的神经支配模式已相当完整。3H-NA的高亲和力摄取在胚胎期也逐渐成熟，并在出生后与通过荧光组织化学估计的神经支配程度相关。内源性NA的水平发育较慢，到P48时仅显示成年大鼠水平的60%-80%。与其他海马传入神经的成熟相比，NA神经支配极其早熟。它定位在一些区域，这使得它在组织发生的早期阶段可能具有重要的营养功能。此外，它在快速发育结构中的存在可能导致其最终分布的终末模式相对不如后来到达的内嗅、连合和隔传入神经那样有组织。
