一种重组模型在计算同胞对基因同一性方差中的应用。
Application of a recombination model in calculating the variance of sib pair genetic identity.
作者信息
Risch N, Lange K
出版信息
Ann Hum Genet. 1979 Oct;43(2):177-86. doi: 10.1111/j.1469-1809.1979.tb02010.x.
Abstract
Using a previously described model of crossing over (Risch & Lange, 1979), we have calculated analytically the variance in the proportion of genes identical by descent shared by two sibs. The prior distributions for numbers of chiasmata reported in Suarez et al. (1979) were used to calculate a standard deviation of 0.040 for the 22 human autosomes. It is also shown that any two identity by descent values within a sibship are uncorrelated.
摘要
使用先前描述的交换模型（里斯克和兰格，1979年），我们通过分析计算了两个同胞之间同源基因比例的方差。苏亚雷斯等人（1979年）报告的交叉数的先验分布被用于计算22条人类常染色体的标准差为0.040。研究还表明，同胞关系内的任何两个同源性值都是不相关的。
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