阿洛西林和美洛西林对革兰氏阴性菌的活性：与其他青霉素类药物的比较。
Activity of azlocillin and mezlocillin against gram-negative organisms: comparison with other penicillins.
作者信息
Wise R, Gillett A P, Andrews J M, Bedford K A
出版信息
Antimicrob Agents Chemother. 1978 Apr;13(4):559-65. doi: 10.1128/AAC.13.4.559.
Abstract
The activities of azlocillin and mezlocillin were compared with those of carbenicillin, ticarcillin, and pirbenicillin against a wide range of gram-negative organisms. The two new drugs were considerably more active than carbenicillin against Klebsiella species and Escherichia coli. Carbenicillin was twice as active against Proteus mirabilis as mezlocillin and four times as active as azlocillin. Against Pseudomonas aeruginosa, azlocillin was eight times as active as carbenicillin. Azlocillin and mezlocillin were twice as active as carbenicillin against Bacteroides fragilis, and these drugs showed a high degree of activity against Haemophilus influenzae and Neisseria gonorrhoeae.
摘要
将阿洛西林和美洛西林与羧苄西林、替卡西林和哌拉西林对多种革兰氏阴性菌的活性进行了比较。这两种新药对克雷伯菌属和大肠杆菌的活性比羧苄西林强得多。羧苄西林对奇异变形杆菌的活性是美洛西林的两倍，是阿洛西林的四倍。对铜绿假单胞菌，阿洛西林的活性是羧苄西林的八倍。阿洛西林和美洛西林对脆弱拟杆菌的活性是羧苄西林的两倍，并且这些药物对流感嗜血杆菌和淋病奈瑟菌显示出高度活性。
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