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Bactec血清庆大霉素检测法的评估。

Evaluation of the Bactec serum gentamicin assay.

作者信息

Manos J P, Jacobs P F

出版信息

Antimicrob Agents Chemother. 1979 Nov;16(5):631-4. doi: 10.1128/AAC.16.5.631.

Abstract

A radiometric assay for gentamicin was compared with an established radioimmunoassay protocol. The coefficients of variation for within-run, day-to-day, and overall runs were consistently higher for the radiometric method as compared with the radioimmunoassay. The coefficient of correlation for 84 patient sera tested by the two methods for gentamicin levels was 0.82. Though less precise, the radiometric method was felt to be an acceptable means of determining gentamicin levels in laboratories where the radioimmunoassay is unavailable.

摘要

将庆大霉素的放射测定法与既定的放射免疫测定方案进行了比较。与放射免疫测定法相比,放射测定法在批内、日间和总体测定中的变异系数始终较高。两种方法检测84份患者血清庆大霉素水平的相关系数为0.82。尽管不够精确,但在没有放射免疫测定法的实验室中,放射测定法被认为是测定庆大霉素水平的一种可接受的方法。

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本文引用的文献

1
Pharmacology of gentamicin in man.庆大霉素在人体中的药理学。
J Infect Dis. 1971 Dec;124 Suppl:S98-105. doi: 10.1093/infdis/124.supplement_1.s98.
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Enzymatic assay for gentamicin and related aminoglycoside antibiotics.
J Infect Dis. 1974 May;129(5):519-27. doi: 10.1093/infdis/129.5.519.
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Automated detection of Haemophilus influenzae.流感嗜血杆菌的自动检测
Appl Microbiol. 1973 Jun;25(6):1011-2. doi: 10.1128/am.25.6.1011-1012.1973.
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A rapid chemical assay for gentamicin.庆大霉素的快速化学检测法。
N Engl J Med. 1972 Mar 16;286(11):583-6. doi: 10.1056/NEJM197203162861106.

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