使用多重耐药肺炎克雷伯菌菌株的庆大霉素快速生物测定法。
Rapid gentamicin bioassay using a multiple-antibiotic-resistant strain of Klebsiella pneumoniae.
作者信息
Lund M E, Blazevic D J, Matsen J M
出版信息
Antimicrob Agents Chemother. 1973 Nov;4(5):569-73. doi: 10.1128/AAC.4.5.569.
Abstract
A rapid bioassay for gentamicin levels in serum was developed by using a strain of Klebsiella pneumoniae that has multiple resistance to antibiotics. Assays were comparable when performed on either small or large petri plates, and results were available in 2 to 4 h. Studies showed an overall recovery of 97.6% for gentamicin alone or 104.5% in the presence of commonly used antibiotics. The procedure can be performed without the need to inactivate other antibiotics that may be present in the serum sample.
摘要
通过使用对多种抗生素具有多重耐药性的肺炎克雷伯菌菌株，开发了一种用于检测血清中庆大霉素水平的快速生物测定法。在小培养皿或大培养皿上进行测定时结果相当，2至4小时内即可获得结果。研究表明，单独检测庆大霉素时总体回收率为97.6%，在存在常用抗生素的情况下回收率为104.5%。该检测程序无需灭活血清样本中可能存在的其他抗生素即可进行。
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