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酶促乙酰化法作为测定血清氨基糖苷类药物浓度的一种手段。

Enzymatic acetylation as a means of determining serum aminoglycoside concentrations.

作者信息

Haas M J, Davies J

出版信息

Antimicrob Agents Chemother. 1973 Oct;4(4):497-9. doi: 10.1128/AAC.4.4.497.

DOI:10.1128/AAC.4.4.497
PMID:4791309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444583/
Abstract

A rapid and accurate enzymatic assay has been developed for the determination of blood serum levels of BB-K8 and other suitable aminoglycoside antibiotics.

摘要

已开发出一种快速准确的酶法测定血清中BB-K8及其他合适氨基糖苷类抗生素的含量。

相似文献

1
Enzymatic acetylation as a means of determining serum aminoglycoside concentrations.酶促乙酰化法作为测定血清氨基糖苷类药物浓度的一种手段。
Antimicrob Agents Chemother. 1973 Oct;4(4):497-9. doi: 10.1128/AAC.4.4.497.
2
Radioenzymatic assays for aminoglycosides with kanamycin 6'-acetyltransferase.使用卡那霉素6'-乙酰转移酶对氨基糖苷类进行放射酶测定。
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[Enzymatic assays of aminoglycoside antibiotics (author's transl)].氨基糖苷类抗生素的酶促测定（作者译）
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Inhibition of acetylating activity in an enzymatic assay for aminoglycoside antibiotics.在氨基糖苷类抗生素的酶法测定中对乙酰化活性的抑制。
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An improved radioenzymatic assay of aminoglycoside antibiotics in human serum by aminoglycoside 6'-N-acetyltransferase [AAC (6')].利用氨基糖苷6'-N-乙酰基转移酶[AAC(6')]对人血清中氨基糖苷类抗生素进行改进的放射酶法测定。
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Enzymatic adenylylation by aminoglycoside 4'-adenylytransferase and 2"-adenylyltransferase as a means of determining concentrations of aminoglycoside antibiotics in serum.通过氨基糖苷4'-腺苷酸转移酶和2''-腺苷酸转移酶进行酶促腺苷酸化作为测定血清中氨基糖苷类抗生素浓度的一种方法。
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The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity.来自链霉菌的氨基糖苷3-N-乙酰基转移酶对阿贝卡星进行的新型酶促3''-N-乙酰化作用及由此产生的活性。
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Serum protein binding of the aminoglycoside antibiotics.氨基糖苷类抗生素的血清蛋白结合情况。
Antimicrob Agents Chemother. 1972 Sep;2(3):214-6. doi: 10.1128/AAC.2.3.214.

引用本文的文献

1
[Enzymatic assays of aminoglycoside antibiotics].[氨基糖苷类抗生素的酶法测定]
Infection. 1977 Jun;5(2):123-125. doi: 10.1007/BF01642097.
2
Evaluation of amikacin dosage regimes in the low and very low birthweight newborn.低出生体重和极低出生体重新生儿阿米卡星给药方案的评估
Infection. 1980;8 Suppl 3:S 239-42. doi: 10.1007/BF01639588.
3
Performance characteristics of bioassay, radioenzymatic assay, homogeneous enzyme immunoassay, and high-performance liquid chromatographic determination of serum gentamicin.生物测定、放射酶测定、均相酶免疫测定以及血清庆大霉素的高效液相色谱测定的性能特征
Antimicrob Agents Chemother. 1982 Jan;21(1):19-25. doi: 10.1128/AAC.21.1.19.
4
Aminoglycoside dosing in renal transplant patients. Comparison of nomogram and individualized pharmacokinetic methods in patients with shifting renal function.肾移植患者的氨基糖苷类药物给药。肾功能变化患者中列线图法与个体化药代动力学方法的比较。
Ann Surg. 1982 Mar;195(3):287-93. doi: 10.1097/00000658-198203000-00008.
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Biological variability of multiple dose pharmacokinetics of netilmicin in man.奈替米星在人体多剂量药代动力学中的生物学变异性。
Eur J Clin Pharmacol. 1983;24(3):399-406. doi: 10.1007/BF00610062.
6
Serum level monitoring of antibacterial drugs. A review.抗菌药物的血清水平监测。综述。
Clin Pharmacokinet. 1984 Nov-Dec;9(6):475-92. doi: 10.2165/00003088-198409060-00001.
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Improved acetylating radioenzymatic assay of amikacin, tobramycin, and sisomicin in serum.血清中阿米卡星、妥布霉素和西索米星的改进乙酰化放射酶法测定
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Effects of divalent cations on binding of aminoglycoside antibiotics to human serum proteins and to bacteria.二价阳离子对氨基糖苷类抗生素与人血清蛋白及细菌结合的影响。
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Comparison of a radioimmunoassay with an enzymatic assay for gentamicin.庆大霉素放射免疫测定法与酶测定法的比较。
Antimicrob Agents Chemother. 1975 Jan;7(1):107-9. doi: 10.1128/AAC.7.1.107.
10
Properties of the gentamicin acetyltransferase enzyme and application to the assay of aminoglycoside antibiotics.庆大霉素乙酰转移酶的特性及其在氨基糖苷类抗生素测定中的应用。
Antimicrob Agents Chemother. 1975 Aug;8(2):222-3. doi: 10.1128/AAC.8.2.222.

本文引用的文献

1
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.携带R因子的大肠杆菌对氨基糖苷类抗生素的酶促乙酰化作用。
Biochemistry. 1971 May 11;10(10):1787-96. doi: 10.1021/bi00786a009.
2
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.由卡那霉素抗性大肠杆菌无细胞系统使卡那霉素失活后的分离及结构研究
J Antibiot (Tokyo). 1967 Jul;20(3):136-41.
3
Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety.铜绿假单胞菌菌株中由脱氧链霉胺部分的酶促N-乙酰化介导的庆大霉素耐药性。
Biochemistry. 1972 Feb 29;11(5):761-5. doi: 10.1021/bi00755a013.
4
A rapid chemical assay for gentamicin.庆大霉素的快速化学检测法。
N Engl J Med. 1972 Mar 16;286(11):583-6. doi: 10.1056/NEJM197203162861106.
5
Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.
Nature. 1965 Dec 25;208(5017):1301-3. doi: 10.1038/2081301a0.