Tsambaos D, Mahrle G
Arch Dermatol Res. 1979 Oct;266(2):177-80. doi: 10.1007/BF00694626.
The phospholipid pattern of the involved and the uninvolved epidermis from 48 psoriatic patients and of the normal epidermis from 23 healthy controls was determined by thin-layer chromatography. A higher amount of total phospholipids was found only in the involved psoriatic epidermis, whereas significant alterations in the phospholipid pattern were observed in the psoriatic lesion and in the lesion-free epidermis. Namely, the decrease of phosphatidylserine and the increase of phosphatidylinositol were identically present in both the involved and the uninvolved psoriatic epidermis. It seems likely that these alterations in the phospholipid pattern in psoriasis may be related to subclinical alterations of the epidermis in this disease.
采用薄层色谱法测定了48例银屑病患者受累及未受累表皮以及23例健康对照者正常表皮的磷脂模式。仅在银屑病受累表皮中发现总磷脂含量较高，而在银屑病皮损及无皮损表皮中均观察到磷脂模式有显著改变。具体而言，磷脂酰丝氨酸减少和磷脂酰肌醇增加在银屑病受累及未受累表皮中均同样存在。银屑病中磷脂模式的这些改变可能与该疾病表皮的亚临床改变有关。
