拉贝洛尔单药治疗肾功能正常和受损的高血压患者。
Monotherapy with labetalol for hypertensive patients with normal and impaired renal function.
作者信息
Thompson F D, Joekes A M, Hussein M M
出版信息
Br J Clin Pharmacol. 1979;8(Suppl 2):129S-133S.
1 Labetalol was given to 41 hypertensive patients in a divided dosage of 150--2,400 mg daily for periods ranging from 1--64 months. 2 Monotherapy with labetalol was adequate in 12 out of 19 patients with essential hypertension and in 15 out of the 22 with renal hypertension. 3 Following a single dose of labetalol 200 mg orally a hypotensive response was seen between 1.5 and 2 hours. 4 In the doses used there was no exercise or postural hypotension. 5 No reduction in overall renal function attributable to labetalol was seen.
给41例高血压患者使用拉贝洛尔，每日分剂量给药150 - 2400毫克，疗程为1 - 64个月。
19例原发性高血压患者中有12例、22例肾性高血压患者中有15例单用拉贝洛尔治疗有效。
口服单剂量200毫克拉贝洛尔后，1.5至2小时出现降压反应。
使用该剂量时未出现运动性或体位性低血压。
未发现拉贝洛尔导致整体肾功能下降。
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