Lejeune F J, Beaumont L, Garcia Y, Regnier R
Biomedicine. 1978 Jan-Feb;28(1):48-54.
The authors studied the effects of peritoneal macrophages on the growth of HP2 cells, a continuous line isolated from the transplanted Harding-Passey mouse melanoma. They found that normal peritoneal macrophages can exert a strong cytostatic effect on HP2 cells, as expressed by cell number and tritiated thymidine uptake by the target cells. The data indicates that normal heat inactivated sera from various species can render macrophages cytostatic. In addition, normal serum can amplify the cytostatic properties of macrophages from immunized animals. The results are discussed in the light of present knowledge of macrophage metabolism.
作者研究了腹膜巨噬细胞对HP2细胞生长的影响，HP2细胞系是从移植的哈丁-帕西小鼠黑色素瘤中分离出来的连续细胞系。他们发现，正常腹膜巨噬细胞可对HP2细胞产生强烈的细胞抑制作用，这通过靶细胞的细胞数量和氚标记胸腺嘧啶核苷摄取来体现。数据表明，来自不同物种的正常热灭活血清可使巨噬细胞具有细胞抑制作用。此外，正常血清可增强免疫动物巨噬细胞的细胞抑制特性。根据目前对巨噬细胞代谢的了解对结果进行了讨论。
