Schonfeld S E
J Dent Res. 1975 Oct;54 Spec no C:C72-7. doi: 10.1177/002203457505400308011.
Young adult rabbits were immunized with enamel matrix proteins from embryonic tooth organs of the same strain of rabbit. These proteins elicited an alloimmune response as demonstrated by the specific binding of antiserum to enamel matrix which was visualized by indirect immunofluorescent microscopy. The labial and lingual surfaces of embryonic incisor tooth organs were found to share common antigenic determinants. The observations suggest that enamel proteins could possibly be autoantigens.
用来自同一品系兔胚胎牙齿器官的釉质基质蛋白对年轻成年兔进行免疫。这些蛋白引发了同种免疫反应，通过抗血清与釉质基质的特异性结合得以证明，这种结合通过间接免疫荧光显微镜观察到。发现胚胎切牙牙齿器官的唇面和舌面具有共同的抗原决定簇。这些观察结果表明釉质蛋白可能是自身抗原。
