腹膜巨噬细胞作为体外测量病毒特异性T细胞介导的细胞毒性的靶细胞。
Peritoneal macrophages as target cells for measuring virus-specific T cell mediated cytotoxicity in vitro.
作者信息
Zinkernagel R M, Doherty P C
出版信息
J Immunol Methods. 1975 Sep;8(3):263-6. doi: 10.1016/0022-1759(75)90120-9.
PMID:52680
Abstract
In inbred or outbred mice lysis of virally modified cells by thymus-derived lymphocytes occurs only within a H-2 compatible system. Peritoneal macrophages provide a convenient source of syngeneic target cells. They are readily infected in vitro with LCM virus, and show high levels of specific 51Cr release when exposed to T cells from LCM immune mice.
摘要
在近交或远交小鼠中，胸腺来源的淋巴细胞对病毒修饰细胞的裂解仅发生在H-2相容系统内。腹腔巨噬细胞是同基因靶细胞的便捷来源。它们在体外很容易被淋巴细胞脉络丛脑膜炎病毒（LCM病毒）感染，并且当暴露于来自LCM免疫小鼠的T细胞时，会表现出高水平的特异性51Cr释放。
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