HLA - D区域相关决定簇作为人类细胞介导的细胞溶解作用的靶标。
HLA-D region-associated determinants serve as targets for human cell-mediated lysis.
作者信息
Feighery C, Stastny P
出版信息
J Exp Med. 1979 Feb 1;149(2):485-94. doi: 10.1084/jem.149.2.485.
Abstract
Effector cells for cell-mediated lysis (CML) were generated by in vitro culture of lymphocytes from selected donors with X-irradiated cells from unrelated subjects who were HLA-D homozygous and matched to the responders for the antigens of the HLA-A and HLA-B regions. By using chromium labeled monocytes as target cells, cytotoxicity was found to correlate with presence of HLA-D region antigens matching those of the stimulating cells. Such CML reactions apparently directed at products of HLA-D, were inhibited by addition of unlabeled monocytes or B lymphocytes. These unlabeled cells had to be matched for HLA-D with the stimulating cells used to generate the effector populations. The results suggested that products of HLA-D, perhaps the DR antigens, were recognized by cytotoxic lymphocytes.
摘要
通过用来自无关个体的经X射线照射的细胞对选定供体的淋巴细胞进行体外培养，生成了用于细胞介导溶解（CML）的效应细胞。这些无关个体为HLA - D纯合子，且在HLA - A和HLA - B区域的抗原与应答者相匹配。以铬标记的单核细胞作为靶细胞，发现细胞毒性与刺激细胞的HLA - D区域抗原的存在相关，这些抗原与刺激细胞的相匹配。这种明显针对HLA - D产物的CML反应，可通过添加未标记的单核细胞或B淋巴细胞而受到抑制。这些未标记的细胞在HLA - D方面必须与用于产生效应细胞群体的刺激细胞相匹配。结果表明，细胞毒性淋巴细胞能够识别HLA - D的产物，可能是DR抗原。
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本文引用的文献
1
Mixed lymphocyte cultures produce effector cells: model in vitro for allograft rejection.混合淋巴细胞培养产生效应细胞：同种异体移植排斥的体外模型。
Science. 1970 Apr 3;168(3927):133-5. doi: 10.1126/science.168.3927.133.
2
Cell mediated lympholysis in man after sensitization of effector lymphocytes through mixed leukocyte cultures.通过混合淋巴细胞培养使效应淋巴细胞致敏后人体中的细胞介导淋巴细胞溶解作用。
G Batteriol Virol Immunol Ann Osp Maria Vittor Torino. 1971 Sep-Dec;64(9):243-54.
3
Cell-mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse.体外细胞介导的细胞裂解：小鼠中杀伤细胞产生和靶细胞特异性的遗传控制。
Eur J Immunol. 1974 May;4(5):378-87. doi: 10.1002/eji.1830040514.
4
Cell-mediated lympholysis. Importance of serologically defined H-2 regions.细胞介导的淋巴细胞溶解。血清学定义的H-2区域的重要性。
J Exp Med. 1973 May 1;137(5):1303-9. doi: 10.1084/jem.137.5.1303.
5
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Tissue Antigens. 1974;4(4):378-82. doi: 10.1111/j.1399-0039.1974.tb00264.x.
6
7
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Transplant Proc. 1973 Sep;5(3):1301-7.
8
Mixed lymphocyte cultures in rheumatoid arthritis.类风湿关节炎中的混合淋巴细胞培养
J Clin Invest. 1976 May;57(5):1148-57. doi: 10.1172/JCI108382.
9
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Transplant Rev. 1976;30:18-39. doi: 10.1111/j.1600-065x.1976.tb00213.x.
10
Detection of human B lymphocyte alloantigens by complement fixation.通过补体结合法检测人类B淋巴细胞同种抗原
Transplantation. 1977 Sep;24(3):230-4. doi: 10.1097/00007890-197709000-00011.
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