King M A, Wells J V, Nelson D S
Clin Exp Immunol. 1979 Nov;38(2):306-15.
IgA secretion and intracellular IgA synthesis by PWM-stimulated peripheral blood lymphocytes from normal and IgA deficient subjects were measured by radioimmunoassay. Cultured lymphocytes from eleven out of twelve IgA deficient subjects had impaired or undetectable IgA production. Measurement of intracellular IgA showed that the defect was more basic than simply defective secretion by IgA plasma cells. Co-culture of lymphocytes from IgA deficient and normal subjects revealed defects in both the B and T cell populations of IgA deficient subjects. In one subject the defect was in the T cells, in another the B cells, and in two others both T and B cells were defective.
通过放射免疫测定法测量了来自正常和IgA缺陷受试者的经PWM刺激的外周血淋巴细胞的IgA分泌和细胞内IgA合成。12名IgA缺陷受试者中有11名的培养淋巴细胞存在IgA产生受损或无法检测到的情况。细胞内IgA的测量表明，该缺陷比单纯的IgA浆细胞分泌缺陷更为根本。IgA缺陷和正常受试者的淋巴细胞共培养显示IgA缺陷受试者的B细胞和T细胞群体均存在缺陷。在一名受试者中缺陷存在于T细胞，在另一名受试者中存在于B细胞，在另外两名受试者中T细胞和B细胞均有缺陷。
