Vitetta E S, Melcher U, McWilliams M, Lamm M E, Phillips-Quagliata J M, Uhr J W
J Exp Med. 1975 Jan 1;141(1):206-15. doi: 10.1084/jem.141.1.206.
An Ig molecule containing L chains and H chains similar to human delta-chains has been detected on the surface of radioiodinated murine lymphoid cells. Newborn mice have only IgM on their splenocytes. Between 10 and 15 days, the IgD-like molecule appears and increases in amount until 3 mo of age, when it is the predominant cell surface Ig in terms of radioactivity. IgD is found only in peripheral lymphoid tissues and is present in larger amounts on peripheral lymph node cells (approximately 85% of surface Ig) than on splenocytes (approximately 50%). IgD is also present in comparable amounts on cells from both nu/nu and germfree mice, indicating that its expression may be independent of both thymic influence and antigenic stimulation. These studies suggest that there is a switch from cell surface IgM to IgD that occurs during differentiation of virgin B lymphocytes in the spleen.
在放射性碘化的鼠类淋巴细胞表面检测到一种含有与人类δ链相似的轻链和重链的免疫球蛋白（Ig）分子。新生小鼠的脾细胞上仅有IgM。在10至15日龄之间，类IgD分子出现并数量增加，直至3月龄，此时就放射性而言它是主要的细胞表面免疫球蛋白。IgD仅在外周淋巴组织中发现，在外周淋巴结细胞上的含量（约占表面免疫球蛋白的85%）比在脾细胞上（约占50%）更多。在无胸腺裸鼠和无菌小鼠的细胞上，IgD的含量也相当，这表明其表达可能独立于胸腺影响和抗原刺激。这些研究表明，在脾脏中初始B淋巴细胞分化过程中会发生从细胞表面IgM到IgD的转换。
