嵌合犬自身淋巴细胞介导的、并被其血清特异性消除的成纤维细胞集落抑制。
Colony inhibition of fibroblasts from chimeric dogs mediated by the dogs' own lymphocytes and specifically abrogated by their serum.
作者信息
Hellström I, Hellström K E, Storb R, Thomas E D
出版信息
Proc Natl Acad Sci U S A. 1970 May;66(1):65-71. doi: 10.1073/pnas.66.1.65.
Abstract
Nine canine irradiation chimeras were studied between 173 days and 7.5 years after 1200 to 1500 r of total body irradiation and transplantation of allogeneic bone marrow. Skin fibroblasts from chimeras and normal dogs were tested for colony inhibition by exposure to sera and peripheral blood lymphocytes from both chimeric and normal dogs. Lymphocytes from the chimeric dog were found to inhibit colony formation by its "own" fibroblasts while lymphocytes from other chimeras or from normal dogs did not. Serum from the chimera specifically abrogated this inhibitory effect. These results indicate that the immunological "tolerance" of the chimeric dog is mediated in vivo by blocking serum factors.
摘要
对9只犬辐射嵌合体进行了研究，这些犬在接受1200至1500伦琴全身照射及同种异体骨髓移植后173天至7.5年之间。通过将嵌合体和正常犬的血清及外周血淋巴细胞暴露于嵌合体和正常犬的皮肤成纤维细胞，来检测其集落抑制情况。发现嵌合体犬的淋巴细胞可抑制其“自身”成纤维细胞的集落形成，而其他嵌合体或正常犬的淋巴细胞则无此作用。嵌合体的血清可特异性消除这种抑制作用。这些结果表明，嵌合体犬的免疫“耐受”在体内是由阻断血清因子介导的。
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本文引用的文献
1
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Science. 1945 Oct 19;102(2651):400-1. doi: 10.1126/science.102.2651.400.
2
SYNERGIC AND ANTAGONISTIC EFFECTS OF ISOANTIBODY UPON GRAFT-VERSUS-HOST DISEASE.同种抗体对移植物抗宿主病的协同和拮抗作用
Transplantation. 1965 Mar;3:161-9. doi: 10.1097/00007890-196503000-00004.
3
"Killing effect" of injected lymphnode cells in homologous radiation chimeras.同源辐射嵌合体中注射淋巴结细胞的“杀伤效应”
Plast Reconstr Surg. 1962 Oct;30:111-7.
4
Antihost reactivity and tolerance of the graft in relation to secondary disease in radiation chimeras.辐射嵌合体中移植物的抗宿主反应性及对继发性疾病的耐受性
Ann N Y Acad Sci. 1962 Oct 24;99:550-63. doi: 10.1111/j.1749-6632.1962.tb45336.x.
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Proc Natl Acad Sci U S A. 1961 Apr 15;47(4):594-602. doi: 10.1073/pnas.47.4.594.
6
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Fed Proc. 1957 Jul;16(2):581-91.
7
Implantation of functional erythropoietic elements following total-body irradiation.全身照射后功能性造血细胞成分的植入。
Proc Soc Exp Biol Med. 1955 Nov;90(2):512-5. doi: 10.3181/00379727-90-22082.
8
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9
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