肌肉去神经支配对小鼠移植瘤生长的影响。
Effect of muscle denervation on growth of transplanted tumor in mice.
作者信息
Batkin S, Piette L H, Wildman E
出版信息
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1521-7. doi: 10.1073/pnas.67.3.1521.
Abstract
A temporary retardation of transplanted Round Cell Neuroblastoma growth in the gastrocnemius muscle of mice was observed in 20% of the animals after denervation of the muscle. The tumor cells in these denervated animals showed structural alterations and deterioration in function. These altered cells when mixed with associated denervated muscle tissue, to which was added fresh tumor, produced a higher percentage of retardation upon subsequent transplants in innervated muscle.
摘要
在20%的小鼠中，观察到对腓肠肌进行去神经支配后，移植的圆形细胞神经母细胞瘤在该肌肉中的生长出现暂时延缓。这些去神经支配动物体内的肿瘤细胞显示出结构改变和功能退化。当这些改变的细胞与相关的去神经支配肌肉组织混合，并添加新鲜肿瘤后，在随后移植到有神经支配的肌肉中时，产生更高比例的生长延缓。
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