局灶节段性肾小球硬化是一种难治性慢性肾小球肾炎，属于干细胞疾病。
Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder.
作者信息
Nishimura M, Toki J, Sugiura K, Hashimoto F, Tomita T, Fujishima H, Hiramatsu Y, Nishioka N, Nagata N, Takahashi Y
机构信息
First Department of Pathology, Kansai Medical University, Osaka, Japan.
出版信息
J Exp Med. 1994 Mar 1;179(3):1053-8. doi: 10.1084/jem.179.3.1053.
Abstract
The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs.
摘要
局灶节段性肾小球硬化（FGS）的发病机制尚不清楚。我们利用一种新的FGS动物模型（FGS小鼠），在此证明将正常小鼠的骨髓移植到具有高度蛋白尿（+++）的FGS小鼠可改善FGS，并且将FGS小鼠的骨髓细胞或纯化的造血干细胞（HSC）移植到正常小鼠中会诱发FGS。这些发现强烈表明FGS是一种干细胞疾病；异常可能在造血干细胞水平上是由基因编程的。
相似文献
1
Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder.局灶节段性肾小球硬化是一种难治性慢性肾小球肾炎，属于干细胞疾病。
J Exp Med. 1994 Mar 1;179(3):1053-8. doi: 10.1084/jem.179.3.1053.
2
Renal lesions of the FGS strain of mice: a spontaneous animal model of progressive glomerulosclerosis.
Nephron. 1994;66(3):317-25. doi: 10.1159/000187830.
3
Focal and segmental glomerulosclerosis and porteinuria associated with unilateral renal agenesis.局灶节段性肾小球硬化症与单侧肾发育不全相关的蛋白尿
Lab Invest. 1982 Mar;46(3):275-81.
4
Glomerular cells and macrophages in the progression of experimental focal and segmental glomerulosclerosis.实验性局灶节段性肾小球硬化进展过程中的肾小球细胞和巨噬细胞
Am J Pathol. 1989 Apr;134(4):933-45.
5
[Pathological studies on focal glomerular sclerosis (FGS) in rats--Glomerular changes and distribution in the renal cortex].
Nihon Jinzo Gakkai Shi. 1983 Apr;25(4):363-73.
6
Changes of renal lesion-related parameters in FGS/Nga and the parental mouse strains, CBA/N and RFM/Nga.
Exp Anim. 2004 Apr;53(2):97-102. doi: 10.1538/expanim.53.97.
7
Bone marrow transplantation for autoimmune diseases.自身免疫性疾病的骨髓移植
Acta Haematol. 1998;99(3):116-32. doi: 10.1159/000040826.
8
Plasmapheresis and dipyridamole for recurrent focal glomerular sclerosis.
Nephron. 1985;40(2):241-5. doi: 10.1159/000183469.
9
Heparin-binding epidermal growth factor-like growth factor is expressed in the adhesive lesions of experimental focal glomerular sclerosis.肝素结合表皮生长因子样生长因子在实验性局灶节段性肾小球硬化的粘连病变中表达。
Kidney Int. 1999 Jun;55(6):2310-21. doi: 10.1046/j.1523-1755.1999.00469.x.
10
Distinct qualitative differences between normal and abnormal hemopoietic stem cells in vivo and in vitro.正常与异常造血干细胞在体内和体外存在明显的质的差异。
Stem Cells. 1997;15(1):56-62. doi: 10.1002/stem.150056.
引用本文的文献
1
suPAR, a Circulating Kidney Disease Factor.可溶性尿激酶型纤溶酶原激活物受体，一种循环性肾脏疾病因子。
Front Med (Lausanne). 2021 Oct 6;8:745838. doi: 10.3389/fmed.2021.745838. eCollection 2021.
2
Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance.肾脏中的干细胞/祖细胞：特征、归巢、协调和维持。
Stem Cell Res Ther. 2021 Mar 20;12(1):197. doi: 10.1186/s13287-021-02266-0.
3
Extrarenal determinants of kidney filter function.肾脏滤过功能的肾外决定因素。
Cell Tissue Res. 2017 Jul;369(1):211-216. doi: 10.1007/s00441-017-2635-7. Epub 2017 May 30.
4
Intractable diseases treated with intra-bone marrow-bone marrow transplantation.骨髓内-骨髓移植治疗难治性疾病。
Front Cell Dev Biol. 2014 Sep 2;2:48. doi: 10.3389/fcell.2014.00048. eCollection 2014.
5
Pathophysiology and treatment of focal segmental glomerulosclerosis: the role of animal models.局灶节段性肾小球硬化症的病理生理学和治疗：动物模型的作用。
BMC Nephrol. 2013 Apr 1;14:74. doi: 10.1186/1471-2369-14-74.
6
The future of stem cell transplantation in autoimmune disease.干细胞移植治疗自身免疫病的未来。
Clin Rev Allergy Immunol. 2010 Apr;38(2-3):292-7. doi: 10.1007/s12016-009-8159-5.
7
Monoclonal antibodies for podocytopathies: rationale and clinical responses.用于足细胞病的单克隆抗体：原理及临床反应
Nat Rev Nephrol. 2009 Jun;5(6):337-48. doi: 10.1038/nrneph.2009.70.
8
What is the significance of CD34 immunostaining in the extraglomerular and intraglomerular mesangium?CD34免疫染色在肾小球外和肾小球系膜中的意义是什么？
Virchows Arch. 2008 Oct;453(4):321-8. doi: 10.1007/s00428-008-0647-0. Epub 2008 Aug 8.
9
Stem cell mobilization in idiopathic steroid-sensitive nephrotic syndrome.特发性类固醇敏感性肾病综合征中的干细胞动员
Pediatr Nephrol. 2008 Aug;23(8):1251-6. doi: 10.1007/s00467-008-0793-2. Epub 2008 May 6.
10
Treatment of autoimmune diseases in MRL/lpr mice by allogenic bone marrow transplantation plus adult thymus transplantation.同种异体骨髓移植加成年胸腺移植治疗MRL/lpr小鼠的自身免疫性疾病
Clin Exp Immunol. 2007 Mar;147(3):555-63. doi: 10.1111/j.1365-2249.2006.03310.x.
本文引用的文献
1
Prevention of autoimmune inflammatory polyarthritis in male New Zealand black/KN mice by transplantation of bone marrow cells plus bone (stromal cells).
Arthritis Rheum. 1993 Feb;36(2):263-8. doi: 10.1002/art.1780360220.
2
Focal and segmental glomerulosclerosis and porteinuria associated with unilateral renal agenesis.局灶节段性肾小球硬化症与单侧肾发育不全相关的蛋白尿
Lab Invest. 1982 Mar;46(3):275-81.
3
Renal disease in patients with AIDS: a clinicopathologic study.
Clin Nephrol. 1984 Apr;21(4):197-204.
4
Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome.获得性免疫缺陷综合征相关的局灶节段性肾小球硬化
N Engl J Med. 1984 Mar 15;310(11):669-73. doi: 10.1056/NEJM198403153101101.
5
Spontaneous nephrotic syndrome in a genetic rat model.基因大鼠模型中的自发性肾病综合征
Am J Pathol. 1984 Dec;117(3):400-8.
6
Focal glomerular sclerosis in aminonucleoside nephropathy.氨基核苷肾病中的局灶性肾小球硬化
Tohoku J Exp Med. 1981 Mar;133(3):349-60. doi: 10.1620/tjem.133.349.
7
Focal sclerosing glomerulonephropathy with segmental hyalinosis. A clinicopathologic analysis.局灶性硬化性肾小球肾炎伴节段性玻璃样变。一项临床病理分析。
Lab Invest. 1973 May;28(5):533-44.
8
Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation.通过同种异体骨髓移植预防非肥胖糖尿病小鼠的I型糖尿病。
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7743-7. doi: 10.1073/pnas.82.22.7743.
9
Rationale for bone marrow transplantation in the treatment of autoimmune diseases.骨髓移植治疗自身免疫性疾病的原理。
Proc Natl Acad Sci U S A. 1985 Apr;82(8):2483-7. doi: 10.1073/pnas.82.8.2483.
10
Isolation of murine pluripotent hemopoietic stem cells in the Go phase.
Biochem Biophys Res Commun. 1987 Sep 15;147(2):687-94. doi: 10.1016/0006-291x(87)90985-5.
Zotero 插件