正常及猿猴病毒40转化的3T3小鼠成纤维细胞的血清因子需求
Serum factor requirements of normal and simian virus 40-transformed 3T3 mouse fibroplasts.
作者信息
Paul D, Lipton A, Klinger I
出版信息
Proc Natl Acad Sci U S A. 1971 Mar;68(3):645-52. doi: 10.1073/pnas.68.3.645.
Abstract
Evidence is presented to show the presence in normal rat serum of four different serum factors essential for growth of 3T3 or SV40-transformed 3T3 mouse fibroblasts: a factor that specifically promotes growth of normal 3T3 cells; two factors that specifically promote growth of transformed 3T3 cells; and a factor that sustains viability of both normal and transformed 3T3 cells in serum-free medium, probably without inducing growth of the cells. These factors are separated and partially purified.
摘要
有证据表明，正常大鼠血清中存在四种对3T3或SV40转化的3T3小鼠成纤维细胞生长至关重要的不同血清因子：一种特异性促进正常3T3细胞生长的因子；两种特异性促进转化的3T3细胞生长的因子；以及一种在无血清培养基中维持正常和转化的3T3细胞活力的因子，可能不会诱导细胞生长。这些因子被分离并部分纯化。
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