英国流感病毒血凝素参考制剂。
The British reference preparation for influenza virus haemagglutinin.
作者信息
Westwood M, Woodward P M, Perkins F T
出版信息
J Hyg (Lond). 1971 Jun;69(2):263-71. doi: 10.1017/s0022172400021495.
The two methods for measuring the haemagglutinin content of an influenza virus suspension are the haemagglutinating (HA) and chick cell agglutinating (CCA) techniques and both measure the same biological activity. With the establishment of an international reference preparation for influenza virus haemagglutinin (type A), however, it seems logical to express the haemagglutinin content of influenza vaccines in international units. Accordingly a collaborative study was arranged in order to obtain agreement on the number of units to be assigned to a British reference preparation for influenza haemagglutinin. It was agreed that the preparation contains 190 i.u. per ampoule and 1 i.u. is contained in 0.0622 mg. of the dried material.
测量流感病毒悬液血凝素含量的两种方法是血凝（HA）技术和鸡胚细胞凝集（CCA）技术，二者测量的是相同的生物学活性。然而，随着甲型流感病毒血凝素国际参考品的建立，用国际单位来表示流感疫苗的血凝素含量似乎是合理的。因此，安排了一项协作研究，以便就赋予英国流感血凝素参考品的单位数量达成一致意见。商定该制品每安瓿含190国际单位，0.0622mg干燥材料含1国际单位。
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