接种当前或早期甲型（H3N2）流感灭活毒株的志愿者对攻击的免疫力。
Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2).
作者信息
Larson H E, Tyrrell D A, Bowker C H, Potter C W, Schild G C
出版信息
J Hyg (Lond). 1978 Apr;80(2):243-8. doi: 10.1017/s0022172400053596.
Abstract
Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong Kong/8/73. Preliminary experiments showed that the 30 c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the 'current' 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but that the vaccine prepared from the current strain gave more.
摘要
志愿者接种了由30c突变株、A/查尔姆斯港/73或B/香港/8/73制成的疫苗。初步实验表明，30c毒株在抗原性上与A/香港/8/68相当接近。接种30c的志愿者产生了针对1973年“当前”血清型（以及疫苗病毒）的血凝抑制抗体，但滴度低于接种A/PC/73疫苗后的滴度。然后，通过鼻内接种，用具有A/芬兰/4/74抗原的减毒活病毒WRL 105对志愿者进行攻击。接种B/香港/8/73后感染率为43%，接种30c后为20%，接种A/PC/73后为5%。这表明30c提供了一定的保护，但由当前毒株制备的疫苗提供的保护更多。
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