G1549是一种新的环异羟肟酸抗生素，从产碱假单胞菌的培养液中分离得到。

G1549, a new cyclic hydroxamic acid antibiotic, isolated from culture broth of Pseudomonas alcaligenes.

作者信息

Barker W R, Callaghan C, Hill L, Noble D, Acred P, Harper P B, Sowa M A, Fletton R A

出版信息

J Antibiot (Tokyo). 1979 Nov;32(11):1096-103. doi: 10.7164/antibiotics.32.1096.

DOI:10.7164/antibiotics.32.1096

Abstract

Antibiotic G1549, isolated from culture broth of Pseudomonas alcaligenes, is a new cyclic hydroxamic acid with a 1-hydroxy-2(1H)-pyridinone structure that complexes with metals. The structure of G1549 is suggested to be 1-hydroxy-5-methoxy-6-methyl-2(1H)-pyridinone. In vitro, G1549 and its copper and ferric complexes show moderate activity against Gram-positive bacteria, fungi and Trichomonas vaginalis. Topical application of G1549 and its copper and ferric complexes protect guinea pigs against cutaneous infection with Microsporum canis. The compounds, however, have some systemic toxicity in mice.

摘要

从产碱假单胞菌培养液中分离出的抗生素G1549是一种新型环异羟肟酸，具有与金属络合的1-羟基-2(1H)-吡啶酮结构。G1549的结构被认为是1-羟基-5-甲氧基-6-甲基-2(1H)-吡啶酮。在体外，G1549及其铜和铁络合物对革兰氏阳性菌、真菌和阴道毛滴虫显示出中等活性。局部应用G1549及其铜和铁络合物可保护豚鼠免受犬小孢子菌的皮肤感染。然而，这些化合物对小鼠有一定的全身毒性。