抗生素U - 58,431的发酵、分离、特性及结构

Fermentation, isolation, characterization and structure of antibiotic U-58,431.

作者信息

Slechta L, Chidester C G, Reusser F

出版信息

J Antibiot (Tokyo). 1980 Sep;33(9):919-23. doi: 10.7164/antibiotics.33.919.

DOI:10.7164/antibiotics.33.919

Abstract

A new antibiotic U-58,431 has been isolated from the fermentation broth of Streptomyces helicus DIETZ and LI, sp. n. (UC-5837) and the structure of this antibiotic, namely, 6-amino-3,4,5,8-tetrahydro-4,9-dihydroxy-3-methyl-5,8-dioxo-1,4-ethano-1H-2-benzopyron-7-carboxamide has been determined by X-ray crystallography. The antibiotic inhibits a variety of Gram-positive and Gram-negative bacteria in vitro. However, it is toxic to mice and does not protect experimentally infected animals when administered at the maximum tolerated dose.

摘要

一种新的抗生素U-58,431已从螺旋链霉菌DIETZ和LI（新种，UC-5837）的发酵液中分离出来，并且通过X射线晶体学确定了这种抗生素的结构，即6-氨基-3,4,5,8-四氢-4,9-二羟基-3-甲基-5,8-二氧代-1,4-乙内酰脲-1H-2-苯并吡喃-7-甲酰胺。该抗生素在体外抑制多种革兰氏阳性和革兰氏阴性细菌。然而，它对小鼠有毒，并且在以最大耐受剂量给药时不能保护实验感染的动物。

相似文献

1

Fermentation, isolation, characterization and structure of antibiotic U-58,431.抗生素U - 58,431的发酵、分离、特性及结构

J Antibiot (Tokyo). 1980 Sep;33(9):919-23. doi: 10.7164/antibiotics.33.919.

2

Isolation and characterization of a new antibiotic U-62162.新型抗生素U-62162的分离与特性研究

J Antibiot (Tokyo). 1982 May;35(5):556-60. doi: 10.7164/antibiotics.35.556.

3

FR-900137, a new antibiotic. I. Taxonomy and fermentation of the organism, and isolation and characterization of the antibiotic.FR - 900137，一种新型抗生素。I. 产生该抗生素的微生物的分类学与发酵，以及抗生素的分离与特性分析

J Antibiot (Tokyo). 1980 Mar;33(3):272-9. doi: 10.7164/antibiotics.33.272.

4

Isolation, characterization and structures of PA-46101 A and B.PA - 46101 A和B的分离、表征及结构

J Antibiot (Tokyo). 1990 Jul;43(7):739-47. doi: 10.7164/antibiotics.43.739.

5

Defucogilvocarcin V, a new antibiotic from Streptomyces arenae 2064: isolation, characterization, partial synthesis and biological activity.地夫可吉霉素V，一种来自沙氏链霉菌2064的新型抗生素：分离、表征、部分合成及生物活性。

J Antibiot (Tokyo). 1985 Sep;38(9):1280-3. doi: 10.7164/antibiotics.38.1280.

6

Lavendomycin, a new antibiotic. I. Taxonomy, isolation and characterization.薰衣草霉素，一种新型抗生素。I. 分类学、分离与特性鉴定。

J Antibiot (Tokyo). 1985 Jun;38(6):691-8. doi: 10.7164/antibiotics.38.691.

7

Boholmycin, a new aminoglycoside antibiotic. I. Production, isolation and properties.

J Antibiot (Tokyo). 1988 Jul;41(7):855-61. doi: 10.7164/antibiotics.41.855.

8

G7063-2, a new nitrogen-containing antibiotic of the epoxydon group, isolated from the fermentation broth of a species of Streptomyces.

J Antibiot (Tokyo). 1977 Jun;30(6):455-9. doi: 10.7164/antibiotics.30.455.

9

A new antibiotic,, asukamycin, produced by Streptomyces.一种由链霉菌产生的新型抗生素，明日霉素。

J Antibiot (Tokyo). 1976 Sep;29(9):876-81. doi: 10.7164/antibiotics.29.876.

10

FR-900148, a new antibiotic. I. Taxonomy, fermentation, isolation and characterization.

J Antibiot (Tokyo). 1980 Mar;33(3):259-66. doi: 10.7164/antibiotics.33.259.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。