Slechta L, Chidester C G, Reusser F
J Antibiot (Tokyo). 1980 Sep;33(9):919-23. doi: 10.7164/antibiotics.33.919.
A new antibiotic U-58,431 has been isolated from the fermentation broth of Streptomyces helicus DIETZ and LI, sp. n. (UC-5837) and the structure of this antibiotic, namely, 6-amino-3,4,5,8-tetrahydro-4,9-dihydroxy-3-methyl-5,8-dioxo-1,4-ethano-1H-2-benzopyron-7-carboxamide has been determined by X-ray crystallography. The antibiotic inhibits a variety of Gram-positive and Gram-negative bacteria in vitro. However, it is toxic to mice and does not protect experimentally infected animals when administered at the maximum tolerated dose.
一种新的抗生素U-58,431已从螺旋链霉菌DIETZ和LI（新种，UC-5837）的发酵液中分离出来，并且通过X射线晶体学确定了这种抗生素的结构，即6-氨基-3,4,5,8-四氢-4,9-二羟基-3-甲基-5,8-二氧代-1,4-乙内酰脲-1H-2-苯并吡喃-7-甲酰胺。该抗生素在体外抑制多种革兰氏阳性和革兰氏阴性细菌。然而，它对小鼠有毒，并且在以最大耐受剂量给药时不能保护实验感染的动物。
