从恒河猴自发性乳腺癌中分离出的病毒粒子的DNA聚合酶活性和核酸成分。
DNA polymerase activities and nucleic acid components of virions isolated from a spontaneous mammary carcinoma from a rhesus monkey.
作者信息
Schlom J, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1613-7. doi: 10.1073/pnas.68.7.1613.
Abstract
Virions isolated from a spontaneous mammary carcinoma of a rhesus monkey and propagated in human cells possess an RNA-instructed DNA polymerase. They also exhibit DNA polymerase activities that respond to either double-stranded DNA or synthetic RNA.DNA hybrid complexes as templates. The virion has been shown to have a density of 1.16 g/ml and to contain a nucleic acid species of high molecular weight (sedimentation coefficient, 60-70 S), which bands as RNA at 1.670 in a Cs(2)SO(4) equilibrium density gradient. In addition, the virions contain species of low molecular weight (4-6 S) that consist of RNA as well as components banding at densities characteristic of DNA.RNA complexes. The nucleoid of this virion has been isolated and shown to have a density of 1.23 g/ml; it also contains a 60-70S nucleic acid species.
摘要
从恒河猴自发性乳腺癌中分离并在人细胞中传代培养的病毒粒子含有一种RNA指导的DNA聚合酶。它们还表现出对双链DNA或合成RNA-DNA杂交复合物作为模板有反应的DNA聚合酶活性。已证明该病毒粒子的密度为1.16 g/ml，含有一种高分子量的核酸种类（沉降系数为60-70 S），在Cs₂SO₄平衡密度梯度中于1.670处呈RNA条带。此外，病毒粒子含有低分子量种类（4-6 S），其由RNA以及在DNA-RNA复合物特征密度处呈条带的成分组成。该病毒粒子的核仁已被分离出来，其密度为1.23 g/ml；它还含有一种60-70S的核酸种类。
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