恶性组织中RNA指导的DNA聚合酶和高分子量RNA的检测
Detection of RNA-instructed DNA polymerase and high molecular weight RNA in malignant tissue.
作者信息
Gulati S C, Axel R, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2020-4. doi: 10.1073/pnas.69.8.2020.
Abstract
An experimental procedure is detailed that permits the detection of 70S RNA-directed DNA synthesis in mouse mammary carcinomas. The DNA synthesized is complementary to the RNA of the mouse mammary tumor virus by molecular hybridization, thus, completing the proof that an RNA-instructed DNA polymerase has been identified. Further, RNA-instructed DNA polymerase and its 70S RNA template are physically associated in a particle that has a density characteristic of oncornaviruses. These experiments now provide the technology required to perform similar examinations of human neoplasias.
摘要
详细介绍了一种实验程序，该程序可检测小鼠乳腺癌中70S RNA指导的DNA合成。通过分子杂交，合成的DNA与小鼠乳腺肿瘤病毒的RNA互补，从而完成了已鉴定出RNA指导的DNA聚合酶的证明。此外，RNA指导的DNA聚合酶及其70S RNA模板在具有肿瘤病毒密度特征的颗粒中物理结合。这些实验现在提供了对人类肿瘤进行类似检查所需的技术。
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本文引用的文献
1
Viral-related RNA in Hodgkins' disease and other human lymphomas.霍奇金病及其他人类淋巴瘤中与病毒相关的RNA
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1727-31. doi: 10.1073/pnas.69.7.1727.
2
Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma.小鼠乳腺癌细胞中病毒特异性RNA翻译的证据。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):535-8. doi: 10.1073/pnas.69.3.535.
3
RNA in human leukemic cells related to the RNA of a mouse leukemia virus (leukocytes-RNA-DNA hybridization-rauscher virus-polysomal RNA).人类白血病细胞中的RNA与小鼠白血病病毒的RNA相关（白细胞-RNA-DNA杂交-劳斯氏病毒-多聚核糖体RNA）
Proc Natl Acad Sci U S A. 1972 Feb;69(2):435-9. doi: 10.1073/pnas.69.2.435.
4
Detection of high-molecular-weight RNA in particles from human milk.人乳中颗粒内高分子量RNA的检测
Science. 1972 Feb 4;175(4021):542-4. doi: 10.1126/science.175.4021.542.
5
Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA.人类乳腺癌中存在与小鼠乳腺肿瘤病毒RNA同源的RNA。
Nature. 1972 Jan 7;235(5332):32-6. doi: 10.1038/235032a0.
6
Human sarcomas contain RNA related to the RNA of a mouse leukemia virus.人类肉瘤含有与小鼠白血病病毒RNA相关的RNA。
Science. 1972 Jan 14;175(4018):182-5. doi: 10.1126/science.175.4018.182.
7
Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses.同时检测致癌RNA病毒特有的逆转录酶和高分子量RNA。
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8
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