Fitch W L, Anderson P J, Smith D H
J Chromatogr. 1979 Mar 1;162(3):249-59. doi: 10.1016/s0378-4347(00)81512-1.
An application of the HISLIB program for the comparison of gas chromatographic-mass spectrometric profiles of urinary organic acids isolated by extraction and ion-exchange methods is described. Ion-exchange methods are clearly superior to solvent extraction in terms of the variety of compounds isolated. However, the former method has practical difficulties which make solvent extraction more attractive for rapid analyses. For the compounds isolated by both methods, the precision of analysis is similar, with standard deviations of relative concentration in the range 10--30% for most compounds.
本文描述了HISLIB程序在比较通过萃取和离子交换方法分离的尿有机酸的气相色谱-质谱图方面的应用。就分离出的化合物种类而言，离子交换方法明显优于溶剂萃取法。然而，前一种方法存在实际困难，这使得溶剂萃取法在快速分析中更具吸引力。对于通过两种方法分离出的化合物，分析精度相似，大多数化合物的相对浓度标准偏差在10%-30%范围内。
