促红细胞生成素在大鼠7,12-二甲基苯并(a)蒽诱导急性染色体畸变和白血病中的作用。
Role of erythropoietin in 7,12-dimethylbenz(a)anthracene induction of acute chromosome aberration and leukemia in the rat.
作者信息
Sugiyama T
出版信息
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2761-4. doi: 10.1073/pnas.68.11.2761.
The incidence of chromosome aberrations in rat bone marrow, examined 6 hr after the administration of 7,12-dimethylbenz(a)anthracene, was significantly enhanced by induction of anemia 0-48 hr before the carcinogen treatment and was suppressed by induction of polycythemia. The suppressive influence of polycythemia was reversed by sheep erythropoietin injected shortly before or after the carcinogen injection; this suppressive effect was proportional to the dose of erythropoietin used. These data suggest that erythropoietin is essential to make bone-marrow cells susceptible to chromosome aberrations with 7,12-dimethylbenz(a)anthracene. The incidence of carcinogen-induced leukemia was also increased by anemia and suppressed by polycythemia induction.
在给予7,12 - 二甲基苯并(a)蒽6小时后检测大鼠骨髓中的染色体畸变发生率，结果显示，在致癌物处理前0 - 48小时诱发贫血会显著提高该发生率，而诱发红细胞增多症则会抑制该发生率。在致癌物注射前不久或之后注射羊促红细胞生成素可逆转红细胞增多症的抑制作用；这种抑制作用与所用促红细胞生成素的剂量成正比。这些数据表明，促红细胞生成素对于使骨髓细胞易受7,12 - 二甲基苯并(a)蒽诱导的染色体畸变影响至关重要。致癌物诱发白血病的发生率也因贫血而增加，因诱发红细胞增多症而受到抑制。
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