Kluge N, Ostertag W, Sugiyama T, Arndt-Jovin D, Steinheider G, Furusawa M, Dube S K
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1237-40. doi: 10.1073/pnas.73.4.1237.
Permanent cell lines from transplantable tumors from 7, 12-dimethylbenz(a)anthracene-induced erythroleukemia of the rat were established. These cell lines maintain their erythroid nature. Erythroid differentiation can be induced by dimethylsulfoxide. This is shown by decrease in cell size, appearance of red and benzidine positive cells, and induced synthesis of four out of six adult globin chains.
建立了来自7,12-二甲基苯并(a)蒽诱导的大鼠红白血病可移植肿瘤的永久细胞系。这些细胞系保持其红系特性。二甲亚砜可诱导红系分化。这表现为细胞大小减小、出现红色和联苯胺阳性细胞,以及诱导合成六种成人珠蛋白链中的四种。