芳基烃羟化酶与多环烃肿瘤发生：酶抑制剂7,8-苯并黄酮对肿瘤发生及大分子结合的影响
Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.
作者信息
Kinoshita N, Gelboin H V
出版信息
Proc Natl Acad Sci U S A. 1972 Apr;69(4):824-8. doi: 10.1073/pnas.69.4.824.
Abstract
Aryl hydrocarbon hydroxylase is present and is inducible in mouse skin. 7,8-Benzoflavone, an inhibitor of the enzyme, markedly inhibits tumorigenesis by 7,12-dimethylbenz(a)anthracene, but has either no effect on or stimulates benzo(a)pyrene tumorigenesis. Thus, the role of aryl hydrocarbon hydroxylase appears highly specific for each polycyclic hydrocarbon, in respect to detoxification and/or activation of the hydrocarbon to a carcinogenic form. In parallel studies, we found that 7,8-benzoflavone significantly reduces the amount of 7,12-dimethylbenz(a)anthracene binding to mouse skin DNA, RNA, and protein, and the binding of benzo(a)pyrene to RNA and protein of mouse skin. 7,8-Benzoflavone exhibited a markedly lesser effect on the binding of benzo(a)pyrene to DNA.
摘要
芳烃羟化酶存在于小鼠皮肤中且可被诱导。该酶的抑制剂7,8-苯并黄酮可显著抑制7,12-二甲基苯并(a)蒽的致癌作用，但对苯并(a)芘的致癌作用要么没有影响，要么有促进作用。因此，就多环芳烃的解毒和/或将其激活为致癌形式而言，芳烃羟化酶的作用对每种多环芳烃似乎都具有高度特异性。在平行研究中，我们发现7,8-苯并黄酮可显著减少7,12-二甲基苯并(a)蒽与小鼠皮肤DNA、RNA和蛋白质的结合，以及苯并(a)芘与小鼠皮肤RNA和蛋白质的结合。7,8-苯并黄酮对苯并(a)芘与DNA结合的影响明显较小。
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Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.芳基烃羟化酶与多环烃肿瘤发生：酶抑制剂7,8-苯并黄酮对肿瘤发生及大分子结合的影响
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