Heffernan W P, Guion C, Bull R J
J Environ Pathol Toxicol. 1979 Jul-Aug;2(6):1501-10.
The ability of sodium chlorite to react with constituents of the erythrocyte, in vitro, was examined and compared to that of nitrite. The oxidative damage resulting from chlorite is fundamentally different from that of nitrite. Nitrite is slightly more potent as an oxidant of hemoglobin, while chlorite appears to be less specific in its oxidation of cellular constituents. Unlike nitrite, chlorite was found to deplete erythrocyte glutathione, which was accompanied by an increase in hydrogen peroxide generation. Chlorite also produced substantial changes in erythrocyte membrane morphology. These effects of chlorite are characteristic of compounds that produce oxidant-induced hemolytic anemia in vivo.
在体外研究了亚氯酸钠与红细胞成分发生反应的能力，并将其与亚硝酸盐的反应能力进行了比较。亚氯酸盐造成的氧化损伤与亚硝酸盐造成的氧化损伤有根本区别。亚硝酸盐作为血红蛋白的氧化剂，其氧化能力稍强，而亚氯酸盐在氧化细胞成分方面似乎特异性较低。与亚硝酸盐不同，研究发现亚氯酸盐会消耗红细胞谷胱甘肽，同时过氧化氢生成增加。亚氯酸盐还使红细胞膜形态发生了显著变化。亚氯酸盐的这些作用是体内产生氧化剂诱导的溶血性贫血的化合物所具有的特征。
