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1
Phenyldiimide, hemoglobin, and Heinz bodies.苯基二亚胺、血红蛋白和海因茨小体。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):485-92. doi: 10.1073/pnas.67.2.485.
2
Reaction of phenylhydrazine with erythrocytes. Cross-linking of spectrin by disulfide exchange with oxidized hemoglobin.苯肼与红细胞的反应。通过与氧化血红蛋白的二硫键交换实现血影蛋白交联。
Biochem Pharmacol. 1984 Sep 1;33(17):2739-48. doi: 10.1016/0006-2952(84)90690-7.
3
Oxidation of phenylhydrazines in the presence of oxyhaemoglobin and the origin of Heinz bodies in erythrocytes.在氧合血红蛋白存在的情况下苯肼的氧化作用以及红细胞中亨氏小体的起源。
Nature. 1954 Feb 27;173(4400):389-91. doi: 10.1038/173389b0.
4
Some aspects of the reactions between hydroxylamine and hemoglobin derivatives.羟胺与血红蛋白衍生物之间反应的某些方面。
J Pharmacol Exp Ther. 1971 May;177(2):440-6.
5
Drug-induced oxidative denaturation of hemoglobin.药物诱导的血红蛋白氧化变性
Semin Hematol. 1973 Oct;10(4):269-78.
6
Altered sulfhydryl reactivity of hemoglobins and red blood cell membranes in congenital Heinz body hemolytic anemia.先天性 Heinz 小体溶血性贫血中血红蛋白和红细胞膜巯基反应性的改变
J Clin Invest. 1968 Dec;47(12):2664-77. doi: 10.1172/JCI105950.
7
The demonstration of ferrihemochrome intermediates in heinz body formation following the reduction of oxyhemoglobin A by acetylphenylhydrazone.
Biochim Biophys Acta. 1975 Jun 26;393(2):404-18. doi: 10.1016/0005-2795(75)90069-0.
8
The formation of Heinz bodies in ghosts of human erythrocytes of adults and newborn infants.
Klin Wochenschr. 1973 Feb 15;51(4):201-3. doi: 10.1007/BF01468345.
9
Oxidative damage by phenylhydrazine diminishes erythrocyte anion transport.苯肼造成的氧化损伤会降低红细胞阴离子转运能力。
Biochim Biophys Acta. 1991 May 7;1064(2):308-14. doi: 10.1016/0005-2736(91)90316-z.
10
Complexes of phenyldiazene (phenyldiimide) with deoxyhemoglobin and ferroheme.苯二氮烯（苯二亚胺）与脱氧血红蛋白和亚铁血红素的复合物。
Biochim Biophys Acta. 1968 Oct 15;165(3):483-9. doi: 10.1016/0304-4165(68)90229-8.

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Tafenoquine: A Step toward Malaria Elimination.泰法诺喹：迈向疟疾消除的一步。
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8-Aminoquinoline Therapy for Latent Malaria.8-氨基喹啉疗法治疗潜伏疟疾。
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3
Difference in rates of the reaction of various mammalian oxyhemoglobins with phenylhydrazine.各种哺乳动物氧合血红蛋白与苯肼反应速率的差异。
Arch Toxicol. 1995;69(3):212-4. doi: 10.1007/s002040050161.
4
Formation of aryl and aryldiazenyl complexes in reactions of arylhydrazines and aryldiazenes with a synthetic model compound of haemoprotein.芳基肼和芳基重氮化合物与血红蛋白合成模型化合物反应中芳基和芳基重氮基配合物的形成
Biochem J. 1986 Nov 15;240(1):81-6. doi: 10.1042/bj2400081.
5
Free-radical production and oxidative reactions of hemoglobin.血红蛋白的自由基产生及氧化反应
Environ Health Perspect. 1985 Dec;64:321-30. doi: 10.1289/ehp.8564321.
6
Structure of hemoglobins Zürich [His E7(63)beta replaced by Arg] and Sydney [Val E11(67)beta replaced by Ala] and role of the distal residues in ligand binding.血红蛋白苏黎世[His E7(63)β被Arg取代]和悉尼[Val E11(67)β被Ala取代]的结构以及远端残基在配体结合中的作用。
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1076-80. doi: 10.1073/pnas.75.3.1076.
7
Ligands and oxidants in ferrihemochrome formation and oxidative hemolysis.高铁血红素形成和氧化溶血过程中的配体与氧化剂
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2556-60. doi: 10.1073/pnas.74.6.2556.
8
Mechanism of oxyhaemoglobin breakdown on reaction with acetylphenylhydrazine.氧合血红蛋白与乙酰苯肼反应时的分解机制。
Biochem J. 1978 Jul 1;173(1):19-26. doi: 10.1042/bj1730019.

本文引用的文献

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Properties of catalase. Catalysis of coupled oxidation of alcohols.过氧化氢酶的性质。醇类的偶联氧化催化作用。
Biochem J. 1945;39(4):293-301.
2
The combining power of normal human hemoglobin for nitrosobenzene.正常人血红蛋白与亚硝基苯的结合能力。
J Biol Chem. 1960 Apr;235:1024-8.
3
GENERATION OF HYDROGEN PEROXIDE IN ERYTHROCYTES BY HEMOLYTIC AGENTS.溶血剂在红细胞中产生过氧化氢
Biochemistry. 1964 Jul;3:895-900. doi: 10.1021/bi00895a006.
4
Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body anemias as an acceleration of red cell aging.氧化溶血与血红蛋白沉淀。I. 海因茨小体贫血作为红细胞衰老的加速过程。
J Clin Invest. 1960 Dec;39(12):1818-36. doi: 10.1172/JCI104206.
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The reactions of some aromatic C-nitroso compounds with haemoglobin.一些芳香族亚硝基化合物与血红蛋白的反应。
Biochem J. 1960 Dec;77(3):519-26. doi: 10.1042/bj0770519.
6
[Reduction of nitrosobenzene to aniline in red blood cells].[红细胞中亚硝基苯还原为苯胺的过程]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1959;235(4):365-72.
7
[Oxidation of aniline to nitrosobenzene in dogs].[狗体内苯胺氧化为亚硝基苯的过程]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1959;235(4):354-9.
8
The formation of hydrogen peroxide in the reaction of oxyhemoglobin with methemoglobin-forming agents.氧合血红蛋白与高铁血红蛋白形成剂反应中过氧化氢的形成。
Arch Biochem Biophys. 1957 Sep;71(1):235-49. doi: 10.1016/0003-9861(57)90025-5.
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The reduction of methemoglobin by phenylhydrazine under anaerobic conditions.
J Biol Chem. 1956 Aug;221(2):1047-55.
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Molecular pathology of human haemoglobin.人类血红蛋白的分子病理学
Nature. 1968 Aug 31;219(5157):902-9. doi: 10.1038/219902a0.

苯基二亚胺、血红蛋白和海因茨小体。

Phenyldiimide, hemoglobin, and Heinz bodies.

作者信息

Itano H A

出版信息

Proc Natl Acad Sci U S A. 1970 Oct;67(2):485-92. doi: 10.1073/pnas.67.2.485.

DOI:10.1073/pnas.67.2.485
PMID:5289003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283233/
Abstract

Phenylhydrazine is oxidized stoichiometrically by two equivalents of ferricyanide to produce phenyldiimide and ferrocyanide. This reaction permits accurate determination of the absorption maxima and molar absorption coefficients of phenyldiimide in aqueous solution. These values are identical or extremely similar to those of phenyldiimide produced by decarboxylation of phenylazoformic acid. Knowledge of the stoichiometry of the reaction confirms an earlier suggestion that phenyldiimide is the product of ferricyanide-oxidized phenylhydrazine that reacts with heme proteins. Homologous structures postulated for phenyldiimideferrihemoglobin and nitrosobenzeneferrohemoglobin suggest a common factor in the production of Heinz bodies after exposure of erythrocytes to phenylhydrazine and to arylamines.

摘要

苯肼被两当量铁氰化物化学计量地氧化，生成苯基二亚胺和亚铁氰化物。该反应可准确测定苯基二亚胺在水溶液中的吸收最大值和摩尔吸收系数。这些值与通过苯偶氮甲酸脱羧产生的苯基二亚胺的值相同或极为相似。反应化学计量的知识证实了早期的一个观点，即苯基二亚胺是铁氰化物氧化苯肼与血红素蛋白反应的产物。为苯基二亚胺高铁血红蛋白和亚硝基苯亚铁血红蛋白假定的同源结构表明，红细胞暴露于苯肼和芳胺后产生海因茨小体存在一个共同因素。