苯基二亚胺、血红蛋白和海因茨小体。
Phenyldiimide, hemoglobin, and Heinz bodies.
作者信息
Itano H A
出版信息
Proc Natl Acad Sci U S A. 1970 Oct;67(2):485-92. doi: 10.1073/pnas.67.2.485.
Abstract
Phenylhydrazine is oxidized stoichiometrically by two equivalents of ferricyanide to produce phenyldiimide and ferrocyanide. This reaction permits accurate determination of the absorption maxima and molar absorption coefficients of phenyldiimide in aqueous solution. These values are identical or extremely similar to those of phenyldiimide produced by decarboxylation of phenylazoformic acid. Knowledge of the stoichiometry of the reaction confirms an earlier suggestion that phenyldiimide is the product of ferricyanide-oxidized phenylhydrazine that reacts with heme proteins. Homologous structures postulated for phenyldiimideferrihemoglobin and nitrosobenzeneferrohemoglobin suggest a common factor in the production of Heinz bodies after exposure of erythrocytes to phenylhydrazine and to arylamines.
摘要
苯肼被两当量铁氰化物化学计量地氧化，生成苯基二亚胺和亚铁氰化物。该反应可准确测定苯基二亚胺在水溶液中的吸收最大值和摩尔吸收系数。这些值与通过苯偶氮甲酸脱羧产生的苯基二亚胺的值相同或极为相似。反应化学计量的知识证实了早期的一个观点，即苯基二亚胺是铁氰化物氧化苯肼与血红素蛋白反应的产物。为苯基二亚胺高铁血红蛋白和亚硝基苯亚铁血红蛋白假定的同源结构表明，红细胞暴露于苯肼和芳胺后产生海因茨小体存在一个共同因素。
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