胰岛素琼脂糖凝胶及胰岛素作用动力学
Insulin-sepharose and the dynamics of insulin action.
作者信息
Oka T, Topper Y J
出版信息
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2066-8. doi: 10.1073/pnas.68.9.2066.
Abstract
In terms of the rate of accumulation of alpha-aminoisobutyric acid, mammary epithelial cells from mature virgin mice respond rapidly to insulin covalently bound to sepharose particles, but do not respond initially to soluble insulin in vitro. The response to insulin-sepharose is prevented if the cells are first exposed to insulin. These observations may provide new insight into the dynamics of insulin action.
摘要
就α-氨基异丁酸的积累速率而言，来自成熟处女小鼠的乳腺上皮细胞对共价结合到琼脂糖颗粒上的胰岛素反应迅速，但在体外最初对可溶性胰岛素无反应。如果细胞先接触胰岛素，对胰岛素-琼脂糖的反应就会被阻止。这些观察结果可能为胰岛素作用的动力学提供新的见解。
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