Widdowson J P, Maxted W R, Pinney A M
J Hyg (Lond). 1971 Dec;69(4):553-64. doi: 10.1017/s0022172400021823.
A streptococcal antigen that is closely associated with the M-antigen, but is not type specific can be detected by means of a complement-fixation test in extracts of M-positive, but not of M-negative, variants of group A streptococci. Purification of acid extracts results in a concomitant increase in the purity both of the type-specific M-antigen and of the M-associated protein (MAP). Antibody to MAP is present in the sera of patients who have had streptococcal infection. The highest titres are found in patients with rheumatic fever.
一种与M抗原密切相关但无型特异性的链球菌抗原,可通过补体结合试验在A组链球菌M阳性而非M阴性变种的提取物中检测到。酸提取物的纯化会使型特异性M抗原和M相关蛋白(MAP)的纯度同时提高。感染过链球菌的患者血清中存在针对MAP的抗体。风湿热患者的抗体滴度最高。