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A组链球菌的一种与M蛋白相关的抗原（MAP）。

An M-associated protein antigen (MAP) of group A streptococci.

作者信息

Widdowson J P, Maxted W R, Pinney A M

出版信息

J Hyg (Lond). 1971 Dec;69(4):553-64. doi: 10.1017/s0022172400021823.

DOI:10.1017/s0022172400021823
PMID:5289717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2131032/
Abstract

A streptococcal antigen that is closely associated with the M-antigen, but is not type specific can be detected by means of a complement-fixation test in extracts of M-positive, but not of M-negative, variants of group A streptococci. Purification of acid extracts results in a concomitant increase in the purity both of the type-specific M-antigen and of the M-associated protein (MAP). Antibody to MAP is present in the sera of patients who have had streptococcal infection. The highest titres are found in patients with rheumatic fever.

摘要

一种与M抗原密切相关但无型特异性的链球菌抗原，可通过补体结合试验在A组链球菌M阳性而非M阴性变种的提取物中检测到。酸提取物的纯化会使型特异性M抗原和M相关蛋白（MAP）的纯度同时提高。感染过链球菌的患者血清中存在针对MAP的抗体。风湿热患者的抗体滴度最高。

相似文献

1
An M-associated protein antigen (MAP) of group A streptococci.A组链球菌的一种与M蛋白相关的抗原（MAP）。
J Hyg (Lond). 1971 Dec;69(4):553-64. doi: 10.1017/s0022172400021823.
2
Immunological heterogeneity among the M-associated protein antigens of group-A streptococci.A组链球菌M相关蛋白抗原间的免疫异质性。
J Med Microbiol. 1976 Feb;9(1):73-88. doi: 10.1099/00222615-9-1-73.
3
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC FEVER, AND GLOMERULONEPHRITIS.链球菌与组织抗原的免疫关系。III. 人血清中与心脏组织发生交叉反应的链球菌抗体的存在。与链球菌感染、风湿热和肾小球肾炎的关联。
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4
Antibody to an M-associated protein antigen of streptococci.抗链球菌M相关蛋白抗原的抗体。
J Med Microbiol. 1971 May;4(2):Pii.
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Autoantibodies to heart and rheumatic fever: the induction of autoimmunity to heart by streptococcal antigen cross-reactive with heart.针对心脏的自身抗体与风湿热：与心脏交叉反应的链球菌抗原诱导对心脏的自身免疫。
Ann N Y Acad Sci. 1965 Jun 30;124(2):904-15. doi: 10.1111/j.1749-6632.1965.tb19014.x.
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M-associated protein antibodies in patients with rheumatic fever.风湿热患者中的M相关蛋白抗体。
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J Clin Invest. 1974 Aug;54(2):439-50. doi: 10.1172/JCI107780.
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Gel-precipitation of streptococcal culture supernates with sera of patients with rheumatic fever and streptococcal infection.用风湿热和链球菌感染患者的血清对链球菌培养上清液进行凝胶沉淀试验。
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Evaluation of micro complement fixation tests for antibodies against group A streptococcal M and M-associated antigens in rabbit and human sera.兔血清和人血清中抗A组链球菌M及M相关抗原抗体的微量补体结合试验评估。
Appl Microbiol. 1974 Jan;27(1):1-4. doi: 10.1128/am.27.1.1-4.1974.

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Serum immunoglobulin A and antibody to M-associated protein in patients with acute glomerulonephritis or rheumatic fever.急性肾小球肾炎或风湿热患者的血清免疫球蛋白A及抗M相关蛋白抗体
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本文引用的文献

1
Preparation and properties of type-specific M antigen isolated from a group A, type 1 hemolytic streptococcus.从A群1型溶血性链球菌中分离出的型特异性M抗原的制备及特性
J Exp Med. 1952 Jul;96(1):71-82. doi: 10.1084/jem.96.1.71.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
Accessory plasma factors involved in the bactericidal test for type-specific antibody to group A Streptococci. II. Human plasma cofactor (s) enhancing opsonization of encapsulated organisms.参与A组链球菌型特异性抗体杀菌试验的辅助血浆因子。II. 增强被膜菌调理作用的人血浆辅因子。
J Exp Med. 1963 Jan 1;117(1):1-17. doi: 10.1084/jem.117.1.1.
4
Technique of complementfixation test applicable to the diagnosis of virus diseases.适用于病毒疾病诊断的补体结合试验技术。
Mon Bull Minist Health Public Health Lab Serv. 1962 May;21:96-104.
5
Opsonization of group A streptococci by complement deficient blood from a patient with hereditary angioneurotic edema.一名患有遗传性血管性水肿患者的补体缺陷血液对A组链球菌的调理作用。
J Immunol. 1967 Jul;99(1):92-7.
6
Skin infections and acute nephritis in American Indian children.美国印第安儿童的皮肤感染和急性肾炎
Pediatrics. 1967 Feb;39(2):263-79.
7
An immunological relationship between the group. A streptococcus and mammalian muscle.A组链球菌与哺乳动物肌肉之间的免疫关系。
J Exp Med. 1966 Oct 1;124(4):661-78. doi: 10.1084/jem.124.4.661.
8
Purification of two fragments of M protein from a strain of group A, type 12 streptococcus.从A组12型链球菌菌株中纯化M蛋白的两个片段。
J Immunol. 1968 Sep;101(3):381-91.
9
Streptococcal infections and epidemic acute glomerulonephritis in South Trinidad.特立尼达岛南部的链球菌感染与流行性急性肾小球肾炎
J Pediatr. 1968 Jun;72(6):871-84. doi: 10.1016/s0022-3476(68)80445-7.
10
Streptococcal anti-desoxyribonuclease B: microtechnique determination.链球菌抗脱氧核糖核酸酶B：微量技术测定
J Lab Clin Med. 1968 May;71(5):867-73.