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Genetic analysis of adenovirus type 2. IX. The physical locations of structural genes.

作者信息

Weber J, Hassell J A

出版信息

J Gen Virol. 1979 Sep;44(3):639-55. doi: 10.1099/0022-1317-44-3-639.

DOI:10.1099/0022-1317-44-3-639
PMID:528980
Abstract

Several virus-specified proteins of adenovirus type 2 (Ad2) and type 5 (Ad5) can be distinguished by their differential electrophoretic mobility in SDS-polyacrylamide gels. By comparing the physical maps of the genomes of interserotypic recombinants between ts mutants of these viruses with the pattern of proteins expressed, the physical locations of some genes can be determined on the adenovirus DNA molecule. The proteins of a total of 103 recombinants were analysed; 44 of these are of known DNA structure. Structural genes for the proteins analysed span the following loci on the conventional adenovirus map: V (30 to 43); III (43 to 44); II and 66K (55 to 57); 100K, 36K, 32K (69 to 71); IV (80 to 90).

摘要

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引用本文的文献

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Nucleotide sequence analysis of a region of adenovirus 5 DNA encoding a hitherto unidentified gene.
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Nucleic Acids Res. 1980 Dec 20;8(24):6033-42. doi: 10.1093/nar/8.24.6033.