Christensen H, Kjolbye E, Aung Tun U
Bull World Health Organ. 1966;35(4):633-40.
The effect of simultaneous BCG and smallpox vaccination and the possible interaction of primary BCG vaccination and smallpox revaccination were studied in 1099 Burmese children arbitrarily allocated to four groups. All were tuberculin-tested and all had received primary smallpox vaccination but had not been vaccinated with BCG. In the first group, no vaccination was performed; in the second, negative reactors received BCG vaccine; the third received smallpox vaccine; and the fourth also received smallpox vaccine, negative reactors also receiving BCG vaccine.Comparison of the "take" of smallpox revaccinations in the third and fourth groups and the post-vaccination tuberculin allergy in the second and fourth groups gave no suggestion of interaction.There was no difference in the take of smallpox revaccination between tuberculin-negative and tuberculin-positive children, nor did smallpox vaccination influence naturally acquired tuberculin allergy.Smallpox revaccination had no apparent effect on the frequency distribution of BCG vaccination lesions, and further smallpox revaccination after one year showed that BCG vaccination had not influenced smallpox immunity.
对1099名缅甸儿童进行了研究，这些儿童被随机分为四组，以探讨同时接种卡介苗和天花疫苗的效果以及初次接种卡介苗与天花复种之间可能存在的相互作用。所有儿童均进行了结核菌素试验，且都已接种过初次天花疫苗，但未接种过卡介苗。第一组未进行任何疫苗接种；第二组中结核菌素试验阴性的儿童接种卡介苗；第三组接种天花疫苗；第四组同样接种天花疫苗，结核菌素试验阴性的儿童还接种卡介苗。比较第三组和第四组天花复种的“接种成功情况”以及第二组和第四组接种疫苗后的结核菌素过敏情况，未发现相互作用的迹象。结核菌素阴性和阳性儿童在天花复种的接种成功情况上没有差异，天花疫苗接种也未影响自然获得的结核菌素过敏。天花复种对卡介苗接种部位损伤的频率分布没有明显影响，一年后的再次天花复种表明卡介苗接种未影响天花免疫力。
