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[使用哥本哈根1331菌株进行卡介苗接种后的保护期(作者译)]

[Duration of protection after BCG vaccination with the 1331 Copenhagen strain (author's transl)].

作者信息

Oehme J, Siegle-Joos H

出版信息

Dtsch Med Wochenschr. 1978 Dec 29;103(52):2070-1. doi: 10.1055/s-0028-1129398.

DOI:10.1055/s-0028-1129398
PMID:729489
Abstract

Children vaccinated in 1975 with different doses of BCG were tested when they were 2 1/2 years old by means of the tine test or, if negative, the tuberculin test at 1 : 100. Of those children who, according to present-day view, had been satisfactorily immunised, 34 of 42 still showed a tuberculin allergy after 2 1/2 years, of those unsatisfactorily vaccinated only 23 of 38. In addition it was found that, contrary to general teaching, positive tuberculin allergy is possible even without scar after a BCG vaccination with the Copenhagen strain (6 of 13). The need of revaccination of tuberculin-negative persons is stressed.

摘要

1975年接种不同剂量卡介苗的儿童在2岁半时通过划痕试验进行检测,若结果为阴性,则采用1:100的结核菌素试验。按照当今的观点,在那些已得到满意免疫的儿童中,42名儿童中有34名在2岁半后仍表现出结核菌素过敏,而在接种效果不佳的儿童中,38名儿童中只有23名出现这种情况。此外还发现,与一般认知相反,使用哥本哈根菌株接种卡介苗后,即使没有疤痕,也有可能出现阳性结核菌素过敏(13名儿童中有6名)。文中强调了对结核菌素阴性者进行复种的必要性。

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