香港病毒神经氨酸酶与其他甲型流感病毒人类毒株神经氨酸酶的抗原关系。
The antigenic relationship of the neuraminidase of Hong Kong virus to that of other human strains of influenza A virus.
作者信息
Schulman J L, Kilbourne E D
出版信息
Bull World Health Organ. 1969;41(3):425-8.
Abstract
Segregation of the haemagglutinin and neuraminidase antigens of 6 representative influenza A2 viruses and the Hong Kong virus by genetic recombination permitted a precise analysis of the antigenic constitution of each virus. Although cross-reactivity of the Hong Kong influenza virus and all 6 influenza A2 strains was demonstrated, the cross-reactivity was shown to be entirely dependent upon and mediated through the viral neuraminidase and not the haemagglutinin. The neuraminidase of the Hong Kong virus is slightly reactive with the neuraminidase of older A2 strains but is apparently identical to the enzyme of the recent (1967-68) variants.
摘要
通过基因重组对6种代表性A2型流感病毒和香港病毒的血凝素和神经氨酸酶抗原进行分离，从而能够对每种病毒的抗原组成进行精确分析。虽然已证明香港流感病毒与所有6种A2型流感毒株存在交叉反应，但这种交叉反应完全依赖于病毒神经氨酸酶并通过它介导，而非血凝素。香港病毒的神经氨酸酶与较老的A2型毒株的神经氨酸酶有轻微反应，但显然与近期（1967 - 1968年）变异株的酶相同。
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