Schild G C, Oxford J S, Dowdle W R, Coleman M, Pereira M S, Chakraverty P
Bull World Health Organ. 1974;51(1):1-11.
A new antigenic variant of the Hong Kong (H3N2) subtype of influenzavirus type A is described. The variant, A/Port Chalmers/1/73 (H3N2), was first isolated in Australasia in the autumn of 1973 and subsequently became the predominant influenza A variant in most areas of the world, replacing the previously prevalent strain A/England/42/72 (H3N2). The 1973 variant shows antigenic differences from former Hong Kong variants in both haemagglutinin and neuraminidase antigens. The application of immuno-double-diffusion tests and single-radial-diffusion tests in the antigenic analysis of new variants of the influenzavirus is also described. It is emphasized that since new variants of the Hong Kong virus have appeared in the successive years 1971, 1972, and 1973, the annual frequency of antigenic "drift" for the Hong Kong virus is higher than was recorded for the "Asian" influenzavirus (H2N2) in the first 5 years of the latter's prevalence from 1957 to 1962, during which period little antigenic variation occurred.
本文描述了甲型流感病毒香港（H3N2）亚型的一种新抗原变异株。该变异株，A/查尔姆斯港/1/73（H3N2），于1973年秋季首次在大洋洲分离得到，随后成为世界上大多数地区的主要甲型流感变异株，取代了之前流行的毒株A/英格兰/42/72（H3N2）。1973年的变异株在血凝素和神经氨酸酶抗原方面均显示出与之前香港变异株的抗原差异。本文还介绍了免疫双扩散试验和单辐射扩散试验在流感病毒新变异株抗原分析中的应用。需要强调的是，由于1971年、1972年和1973年连续出现了香港病毒的新变异株，香港病毒抗原“漂移”的年发生率高于1957年至1962年“亚洲”流感病毒（H2N2）流行的前5年所记录的情况，在那段时期几乎没有发生抗原变异。
