Skarstein A, Svanes K, Varhaug J E, Söreide O
Scand J Gastroenterol. 1979;14(8):897-903.
An ulcer was induced in the anterior wall of the antrum of cats by local injection of acetic acid solution. Carbonized microspheres, 15 +/- 5 microns in diameter, labelled with 141Ce, were used to measure blood flow in different regions and layers of the stomach wall. The radioactivity of a blod reference sample and of tissue samples was determined, and the blood flow was calculated for each tissue sample. The gastric tissue samples were examined microscopically, and the level of gastrin in serum was determined. Two groups of anaesthetized animals were used: in one group of animals blood flow was determined 24 h after ulcer induction and in a group of control animals 24 h after laparotomy. In the ulcer animals the gastric blood flow as increased both in the mucosa and in the muscularis in a zone around the ulcer. Microscopic examination revealed tissue necrosis corresponding to the floor of the ulcer and acute inflammatory changes in the gastric wall around the necrotic area. The serum gastrin concentration tended to increase after ulcer induction.
通过局部注射醋酸溶液在猫胃窦前壁诱发溃疡。使用直径为15±5微米、标记有141铈的碳化微球来测量胃壁不同区域和层次的血流。测定血液参考样本和组织样本的放射性，并计算每个组织样本的血流。对胃组织样本进行显微镜检查，并测定血清胃泌素水平。使用两组麻醉动物：一组在诱发溃疡后24小时测定血流，另一组作为对照动物在剖腹术后24小时测定血流。在溃疡动物中，溃疡周围区域的黏膜和肌层的胃血流量均增加。显微镜检查显示，溃疡底部对应的组织坏死，坏死区域周围的胃壁有急性炎症变化。诱发溃疡后血清胃泌素浓度有升高趋势。
