Tveter K J, Attramadal A, Hannestad R, Otnes B
Scand J Urol Nephrol. 1979;13(3):237-43. doi: 10.3109/00365597909179531.
Sixteen patients with prostatic carcinoma were treated with 200 mg of Cyproterone acetate daily. No other kind of hormonal treatment was given. Transrectal biopsies of the prostate were taken before the treatment was started, and at regular intervals afterwards. The treatment period lasted from 3 to 16 months, with an average of 9 months. A thorough examination of multiple sections from all specimens revealed no convincing signs of cellular involution. The study has demonstrated no specific or significant atrophic changes following Cyproterone acetate therapy. Some possible explanations regarding the effect of Cyproterone acetate on human malignant prostatic tissue are discussed.
16例前列腺癌患者每天接受200毫克醋酸环丙孕酮治疗。未给予其他任何激素治疗。在开始治疗前以及之后定期进行经直肠前列腺活检。治疗期持续3至16个月，平均为9个月。对所有标本的多个切片进行全面检查后，未发现令人信服的细胞退化迹象。该研究表明，醋酸环丙孕酮治疗后未出现特定或显著的萎缩性变化。文中讨论了关于醋酸环丙孕酮对人类恶性前列腺组织作用的一些可能解释。
