病毒感染细胞免疫损伤的抑制或增强。
Inhibition or enhancement of immunological injury of virus-infected cells.
作者信息
Brier A M, Wohlenberg C, Rosenthal J, Mage M, Notkins A L
出版信息
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3073-7. doi: 10.1073/pnas.68.12.3073.
Abstract
Within hours after infection of cells with herpes simplex, vaccinia, influenza, or Newcastle disease virus, new antigens appeared on the surface of infected cells. The interaction of specific antiviral antibody and complement with these antigens resulted in cell destruction, which was quantitated by the release of (51)Cr. A number of factors can influence the degree of cell destruction, including the density of viral antigens on the surface of infected cells, the nature of the antiviral antibody, and the presence of anti-immunoglobulins. The immunological destruction of virus-infected cells may on the one hand serve as a defense mechanism against certain viral infections, while on the other hand it may contribute to the pathology of the host.
摘要
在用单纯疱疹病毒、痘苗病毒、流感病毒或新城疫病毒感染细胞后的数小时内，受感染细胞表面会出现新的抗原。特异性抗病毒抗体和补体与这些抗原的相互作用导致细胞破坏，这通过（51）铬的释放来定量。许多因素会影响细胞破坏的程度，包括受感染细胞表面病毒抗原的密度、抗病毒抗体的性质以及抗免疫球蛋白的存在。病毒感染细胞的免疫破坏一方面可能作为针对某些病毒感染的防御机制，而另一方面可能导致宿主的病理变化。
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Immune lysis of rabies virus-infected cells.狂犬病病毒感染细胞的免疫裂解
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Immunological enhancement as studied by cell culture techniques.通过细胞培养技术研究免疫增强作用。
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