Lämmler G, Herzog H, Saupe E, Schütze H R
Bull World Health Organ. 1971;44(6):751-6.
The antifilarial action of 2-[2-(4-hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazyl) benzimidazole (HOE 33258) was investigated in Mastomys natalensis infected with Litomosoides carinii. The subcutaneous administration of HOE 33258 in a single daily dose for 5 consecutive days, or at other intervals, produced, depending on the dosage, a rapid reduction in the number of microfilariae in the circulating blood. The reduction amounted to more than 90% within 7-14 days after the treatment was started or at the end of the dosage schedule. The small, slow increase in the microfilarial count during a period of 6-7 weeks after treatment ended reached not more than half the number present before treatment. HOE 33258 showed marked activity on the reproductive system of mature female worms, although only few macrofilariae were killed by the drug. The results also demonstrated the usefulness of L. carinii infection of M. natalensis as a model for the evaluation of the filaricidal activity of drugs.
在感染了卡里尼丝虫的南非多乳鼠中研究了2-[2-(4-羟基苯基)-6-苯并咪唑基]-6-(1-甲基-4-哌嗪基)苯并咪唑（HOE 33258）的抗丝虫作用。连续5天每日皮下注射一次HOE 33258，或以其他间隔给药，根据剂量不同，可使循环血液中的微丝蚴数量迅速减少。在开始治疗后7-14天内或给药方案结束时，减少量超过90%。治疗结束后6-7周内，微丝蚴数量缓慢小幅增加，增加量不超过治疗前数量的一半。HOE 33258对成熟雌虫的生殖系统显示出显著活性，尽管该药物仅杀死了少数大丝蚴。结果还证明，南非多乳鼠感染卡里尼丝虫作为评估药物杀丝虫活性的模型是有用的。
