Lämmler G, Herzog H, Schütze H R
Bull World Health Organ. 1971;44(6):765-70.
Comparative studies of the chemotherapeutic activity of various filaricides were carried out and the results in Litomosoides carinii infections of Mastomys natalensis were analysed with special reference to macrofilaricidal activity. The administration of suramin in daily subcutaneous doses of 40 mg per kg of body weight for 5 consecutive days showed marked activity against macrofilariae and killed the adult worms within 6 weeks after the beginning of treatment. The microfilarial count of the circulating blood declined steadily to nearly 0 in more than 2 months after microfilarial production by female worms in the pleural cavities had ceased. Amodiaquine proved to be markedly effective against adult parasites, whereas stibophen, tartar emetic, and the free acid of stibocaptate gave inadequate results.
对各种杀丝虫剂的化疗活性进行了比较研究，并特别参照其对大丝虫的杀灭活性，分析了在南非多乳鼠感染卡氏罗阿丝虫的实验结果。以每千克体重每日40毫克的剂量连续5天皮下注射苏拉明，显示出对大丝虫有显著活性，并在治疗开始后6周内杀死成虫。在雌虫在胸腔内产生微丝蚴停止后两个多月，循环血液中的微丝蚴计数稳步下降至几乎为零。氨酚喹对成虫寄生虫显示出显著疗效，而锑波芬、吐酒石和锑卡酯游离酸的效果不佳。
