对南非多乳鼠卡氏丝状线虫感染的化疗研究。2. 药物对微丝蚴的活性。

Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 2. The activity of drugs against microfilariae.

作者信息

Lämmler G, Herzog H, Schütze H R

出版信息

Bull World Health Organ. 1971;44(6):757-63.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2427873/

Abstract

Comparative investigations of the chemotherapeutic activity of various filaricidal compounds and other anthelmintics were made with Litomosoides carinii infections in Mastomys natalensis, special consideration being given to the microfilaricidal activity of the compounds. Diethylcarbamazine, cyclohexanecarboxylic acid-N-methylpiperazide citrate (HOE 28637a), tetrahydropyranecarboxylic acid-N-methylpiperazide citrate (HOE 29691a), (+/-)-tetramisole, (-)-tetramisole (levamisole), and metrifonate proved highly effective against microfilariae whereas gentian violet, methylene violet, and the anthelmintics metyridine, disophenol, pyrantel tartrate, methylpyrantel tartrate and parbendazole showed no, or only inadequate, activity. The usefulness of L. carinii infections in M. natalensis is discussed and is recommended as a model for chemotherapeutic screening tests and for the quantitative evaluation of microfilaricidal activity.

摘要

利用卡氏罗阿丝虫感染南非多乳鼠，对多种杀丝虫化合物及其他驱虫药的化疗活性进行了比较研究，特别关注了这些化合物的杀微丝蚴活性。乙胺嗪、环己烷羧酸 - N - 甲基哌嗪柠檬酸盐（HOE 28637a）、四氢吡喃羧酸 - N - 甲基哌嗪柠檬酸盐（HOE 29691a）、（±）-四咪唑、（-）-四咪唑（左旋咪唑）和敌百虫对微丝蚴显示出高效，而龙胆紫、亚甲紫以及驱虫药间啶、双酚、酒石酸噻嘧啶、甲基酒石酸噻嘧啶和丙硫苯咪唑则无活性或活性不足。讨论了卡氏罗阿丝虫感染南非多乳鼠在研究中的实用性，并推荐将其作为化疗筛选试验及杀微丝蚴活性定量评估的模型。

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