同种异体移植敏感性的细菌诱导。I. A组链球菌致敏的影响。
The bacterial induction of homograft sensitivity. I. Effects of sensitization with group A streptococci.
作者信息
Chase R M, Rapaport F T
出版信息
J Exp Med. 1965 Oct 1;122(4):721-32. doi: 10.1084/jem.122.4.721.
Abstract
Heat-killed Group A hemolytic streptococci can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. The gross and histologic appearance of these grafts is identical with that observed in similar reactions obtained in guinea pigs sensitized with homologous tissues. The ability of Group A hemolytic streptococci to induce homograft sensitivity in the guinea pig is a property shared by Types 4, 5, 6, 11, 12, 14, and 49 of Group A streptococci.
摘要
热灭活的A组溶血性链球菌可在豚鼠中诱导出一种对皮肤同种异体移植物反应性改变的状态，这种状态与用同源组织致敏所产生的状态无法区分。用从随机选择的无关供体获得的初次皮肤同种异体移植物对适当准备的受体进行攻击，会引发白色移植物反应或加速此类移植物的排斥。这些移植物的大体和组织学外观与在用同源组织致敏的豚鼠中获得的类似反应中观察到的相同。A组溶血性链球菌在豚鼠中诱导同种异体移植物敏感性的能力是A组链球菌4型、5型、6型、11型、12型、14型和49型共有的特性。
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