无菌大鼠淋巴细胞在混合白细胞培养及移植物抗宿主反应中的反应性。
Reactivity of lymphocytes from germfree rats in mixed leukocyte culture and in graft-versus-host reaction.
作者信息
Nielsen H E
出版信息
J Exp Med. 1972 Sep 1;136(3):417-25. doi: 10.1084/jem.136.3.417.
Abstract
The reactivity of lymphoid cells from germfree and conventional CDF rats were compared in mixed leukocyte culture (MLC) with both allogeneic rat leukocytes and with human leukocytes as stimulating cells, and in a graft-versus-host (GVH) assay. There was no difference between germfree and conventional rats in any of these systems. Furthermore, the increase in GVH activity after specific immunization against a strong histocompatibility antigen was small in both cases. The findings are incompatible with the hypothesis that the high proportion of antigen-sensitive cells against strong histocompatibility antigens is caused by cross-reactions between microbial antigens and histocompatibility antigens.
摘要
在混合白细胞培养（MLC）中，将无菌和常规CDF大鼠的淋巴细胞与同种异体大鼠白细胞以及人白细胞作为刺激细胞进行反应性比较，并进行移植物抗宿主（GVH）试验。在这些系统中，无菌大鼠和常规大鼠之间没有差异。此外，在两种情况下，针对强组织相容性抗原进行特异性免疫后，GVH活性的增加都很小。这些发现与以下假设不相符：针对强组织相容性抗原的抗原敏感细胞比例高是由微生物抗原和组织相容性抗原之间的交叉反应引起的。
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