Goto F, Fujita T, Kitani Y, Kanno M, Kamei T, Ishii H
Acta Otolaryngol. 1979;88(5-6):335-42. doi: 10.3109/00016487909137177.
Ninety-one patients suffering from idiopathic sudden hearing loss are presented. Twenty-two patients were given medical treatment (vasodilators, steroid hormones and vitamins) alone (group 1). Forty-nine patients were treated with stellate ganglion block (SGB) plus oxygen hyperbaric therapy (OHP) (group 2) and 20 patients were treated with SGB plus OHP along with medical treatment (group 3). The SGB plus OHP treated patients were given bupivacaine, which induced Moor's anterior approach of SGB and then exposed to oxygen at a pressure of 2.4 ATA for 90 min. In group 1, 69% of the patients treated within one week after onset exhibited over 10 dB pure tone average improvement, with only 33% patients treated one to two weeks after onset experiencing over 10 dB. However, 74% of the patients in group 2 and 100% of the patients in group 3 who were treated within two weeks after onset exhibited over 10 dB improvement. More significantly, of the patients which experienced complete loss of hearing, 83% in group 2 and 100% in group 3, exhibited over 10 dB improvement, compared to only 33% in group 1. Moreover, 8 (40%) patients in group 3 recovered to within 20 dB of their normal hearing levels. In group 2, 17 patients were treated two to six weeks after onset and 12 (71%) patients had over 10 dB improvement. SGB plus OHP therapy was shown effective in the treatment of sudden idiopathic hearing loss even when patients were treated more than two weeks after onset.
本文报告了91例特发性突发性感音神经性听力损失患者。22例患者仅接受药物治疗（血管扩张剂、类固醇激素和维生素）（第1组）。49例患者接受星状神经节阻滞（SGB）加高压氧治疗（OHP）（第2组），20例患者接受SGB加OHP并联合药物治疗（第3组）。接受SGB加OHP治疗的患者给予布比卡因，采用Moor前路法进行SGB，然后在2.4ATA的压力下吸氧90分钟。在第1组中，发病后1周内接受治疗的患者中有69%纯音平均听阈改善超过10dB，而发病后1至2周接受治疗的患者中只有33%有此改善。然而，发病后2周内接受治疗的第2组患者中有74%、第3组患者中有100%纯音平均听阈改善超过10dB。更显著的是，在全聋患者中，第2组有83%、第3组有100%纯音平均听阈改善超过10dB，而第1组中只有33%。此外，第3组中有8例（40%）患者听力恢复到正常听力水平20dB以内。在第2组中，17例患者在发病后2至6周接受治疗，其中12例（71%）患者纯音平均听阈改善超过10dB。即使患者在发病后两周以上接受治疗，SGB加OHP疗法在特发性突发性感音神经性听力损失的治疗中也显示出有效性。
