对乙酰氨基酚对布洛芬所致人胃黏膜损伤的影响。
Effect of acetaminophen on human gastric mucosal injury caused by ibuprofen.
作者信息
Lanza F L, Royer G L, Nelson R S, Rack M F, Seckman C E, Schwartz J H
出版信息
Gut. 1986 Apr;27(4):440-3. doi: 10.1136/gut.27.4.440.
Acetaminophen has been proposed as an agent which protects the gastric mucosa against damage induced by aspirin and other non-steroidal anti-inflammatory agents. In order to evaluate this proposal further, 45 normal human volunteers were divided into three groups (n = 15); group one received ibuprofen 2400 mg daily (600 mg qid); group two received acetaminophen 3900 mg daily (975 mg qid) and group three received both drugs at the same dosages. There was no significant difference in the mucosal injury scores noted at endoscopy between the ibuprofen and the ibuprofen-acetaminophen group. The acetaminophen group had virtually no observed mucosal injury and this was statistically significant in comparison with the other groups (p less than 0.01). We conclude that contrary to previously reported studies using single doses of aspirin, acetaminophen failed to decrease the mucosal injury seen with ibuprofen when given for a period of seven days in combination with acetaminophen.
对乙酰氨基酚被认为是一种可保护胃黏膜免受阿司匹林和其他非甾体抗炎药所致损伤的药物。为进一步评估这一观点，将45名正常人类志愿者分为三组（每组n = 15）；第一组每日服用布洛芬2400毫克（每次600毫克，每日四次）；第二组每日服用对乙酰氨基酚3900毫克（每次975毫克，每日四次）；第三组以相同剂量同时服用这两种药物。在内镜检查时，布洛芬组和布洛芬 - 对乙酰氨基酚组的黏膜损伤评分无显著差异。对乙酰氨基酚组几乎未观察到黏膜损伤，与其他组相比具有统计学意义（p小于0.01）。我们得出结论，与先前使用单剂量阿司匹林的报道研究相反，当与对乙酰氨基酚联合服用七天时，对乙酰氨基酚未能降低布洛芬所致的黏膜损伤。
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