Zwaig N, Lin E C
Science. 1966 Aug 12;153(3737):755-7. doi: 10.1126/science.153.3737.755.
Fructose-1 ,6-diphosphate is a feedback inhibitor of the catabolic enzyme, glycerol kinase, in Escherichia coli. A mutant was isolated which produced a desensitized enzyme. Glucose was no longer as effective in preventing the utilization of exogenous glycerol by cells which synthesized constitutively such an altered enzyme, even though the usual degree of catabolite repression still operated.
果糖-1,6-二磷酸是大肠杆菌中分解代谢酶甘油激酶的反馈抑制剂。分离出了一种产生脱敏酶的突变体。对于组成型合成这种改变酶的细胞，即使通常程度的分解代谢物阻遏仍然起作用，葡萄糖在阻止细胞利用外源甘油方面不再那么有效。
