Custer G M, Briggs B R, Smith R E
Antimicrob Agents Chemother. 1979 Dec;16(6):869-72. doi: 10.1128/AAC.16.6.869.
Platelet function and coagulation were tested after brief in vivo exposure to cefamandole nafate and in the presence of various concentrations of the drug in vitro. Alterations in hemostatic function were observed only with exposure to drug concentrations severalfold higher than those expected to prevail clinically.
在体内短暂暴露于头孢孟多酯钠后以及在体外存在不同浓度药物的情况下,对血小板功能和凝血进行了测试。仅在暴露于比临床预期普遍存在的浓度高几倍的药物浓度时,才观察到止血功能的改变。