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头孢孟多酯钠对血液凝固及血小板功能的影响。

Effect of cefamandole nafate on blood coagulation and platelet function.

作者信息

Custer G M, Briggs B R, Smith R E

出版信息

Antimicrob Agents Chemother. 1979 Dec;16(6):869-72. doi: 10.1128/AAC.16.6.869.

Abstract

Platelet function and coagulation were tested after brief in vivo exposure to cefamandole nafate and in the presence of various concentrations of the drug in vitro. Alterations in hemostatic function were observed only with exposure to drug concentrations severalfold higher than those expected to prevail clinically.

摘要

在体内短暂暴露于头孢孟多酯钠后以及在体外存在不同浓度药物的情况下,对血小板功能和凝血进行了测试。仅在暴露于比临床预期普遍存在的浓度高几倍的药物浓度时,才观察到止血功能的改变。

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本文引用的文献

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Morphology and enumeration of human blood platelets.人体血小板的形态学与计数
J Appl Physiol. 1950 Dec;3(6):365-77. doi: 10.1152/jappl.1950.3.6.365.
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A study of the plasma thrombin time.
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Platelet aggregation and the availability of platelet factor 3.
Br J Haematol. 1966 Nov;12(6):764-76. doi: 10.1111/j.1365-2141.1966.tb00164.x.
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Letter: Coagulopathy with cefazolin in uremia.
N Engl J Med. 1974 Jun 6;290(23):1324. doi: 10.1056/NEJM197406062902317.
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The hemostatic defect produced by carbenicillin.羧苄青霉素产生的止血缺陷。
N Engl J Med. 1974 Aug 8;291(6):265-70. doi: 10.1056/NEJM197408082910601.

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