• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

成功为一名患有严重联合免疫缺陷的儿童进行胎儿肝脏移植。

Successful fetal liver transplantation in a child with severe combined immunodeficiency.

作者信息

Keightley R G, Lawton A R, Cooper M D, Yunis E J

出版信息

Lancet. 1975 Nov 1;2(7940):850-3. doi: 10.1016/s0140-6736(75)90238-x.

DOI:10.1016/s0140-6736(75)90238-x
PMID:53333
Abstract

Following transplantation with allogeneic fetal liver, a boy with a severe combined immunodeficiency and adenosine-deaminase (A.D.A.) deficiency developed immunocompetent T and B cells in an orderly manner. Engraftment was indicated by appearance of A.D.A. activity and donor-lymphocyte and red-cell antigens. The child remained free of major infections until one year later when he developed an ultimately fatal nephrotic syndrome associated with immune-complex glomerulonephritis.

摘要

在接受同种异体胎儿肝脏移植后，一名患有严重联合免疫缺陷和腺苷脱氨酶（A.D.A.）缺乏症的男孩有序地产生了具有免疫活性的T细胞和B细胞。A.D.A.活性以及供体淋巴细胞和红细胞抗原的出现表明移植成功。该患儿在一年时间里未发生严重感染，直到后来患上了最终致命的肾病综合征，伴有免疫复合物性肾小球肾炎。

相似文献

1
Successful fetal liver transplantation in a child with severe combined immunodeficiency.成功为一名患有严重联合免疫缺陷的儿童进行胎儿肝脏移植。
Lancet. 1975 Nov 1;2(7940):850-3. doi: 10.1016/s0140-6736(75)90238-x.
2
Effect of adenosine deaminase replacement therapy on a child of adenosine deaminase deficiency with severe combined immunodeficiency disease.腺苷脱氨酶替代疗法对一名患有严重联合免疫缺陷病的腺苷脱氨酶缺乏症患儿的疗效。
Tohoku J Exp Med. 1979 Jul;128(3):251-8. doi: 10.1620/tjem.128.251.
3
Lymphoma in a patient with severe combined immunodeficiency with adenosine deaminase deficiency, following unsustained engraftment of histoincompatible T cell-depleted bone marrow.一名患有腺苷脱氨酶缺乏的重症联合免疫缺陷患者，在组织不相容的去除T细胞骨髓移植未成功植入后发生淋巴瘤。
J Pediatr. 1986 Mar;108(3):435-8. doi: 10.1016/s0022-3476(86)80892-7.
4
Effect of red cell transfusions, thymic hormone and deoxycytidine in severe combined immunodeficiency due to adenosine deaminase deficiency.红细胞输注、胸腺激素和脱氧胞苷对腺苷脱氨酶缺乏所致重症联合免疫缺陷的影响。
Clin Exp Immunol. 1982 Nov;50(2):303-10.
5
Reconstitution of T- and B-cell function after T-lymphocyte-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency due to adenosine deaminase deficiency.腺苷脱氨酶缺乏所致重症联合免疫缺陷患者在T淋巴细胞去除的单倍体相合骨髓移植后T细胞和B细胞功能的重建
Clin Immunol Immunopathol. 1987 Sep;44(3):317-20. doi: 10.1016/0090-1229(87)90075-4.
6
Severe combined immunodeficiency disease with adenosine deaminase deficiency.伴有腺苷脱氨酶缺乏的重症联合免疫缺陷病
Tohoku J Exp Med. 1979 Oct;129(2):197-202. doi: 10.1620/tjem.129.197.
7
Immunological and metabolic reconstitution following successful bone marrow transplantation from a HLA-identical sibling in an infant with adenosine deaminase deficiency and severe combined immunodeficiency: partial restoration of purine metabolism.一名患有腺苷脱氨酶缺乏症和严重联合免疫缺陷的婴儿接受来自 HLA 相同同胞的成功骨髓移植后的免疫和代谢重建：嘌呤代谢的部分恢复
Adv Exp Med Biol. 1989;253A:543-7. doi: 10.1007/978-1-4684-5673-8_88.
8
[Transplantation of T cell-depleted marrow from parents in a case of severe combined immunodeficiency with adenosine deaminase deficiency].[在一例伴有腺苷脱氨酶缺乏的重症联合免疫缺陷病例中，移植来自父母的T细胞去除的骨髓]
Rinsho Ketsueki. 1987 Sep;28(9):1669-74.
9
Adenosine deaminase deficiency and severe combined immunodeficiency disease.腺苷脱氨酶缺乏症与重症联合免疫缺陷病
Adv Enzymol Relat Areas Mol Biol. 1980;51:167-210. doi: 10.1002/9780470122969.ch4.
10
Bone marrow transplantation in a case of severe combined immunodeficiency with adenosine deaminase deficiency [proceedings].
Pathol Biol (Paris). 1978 Jan;26(1):30-1.

引用本文的文献

1
Fetal stem cell transplantation: Past, present, and future.胎儿干细胞移植：过去、现在与未来。
World J Stem Cells. 2014 Sep 26;6(4):404-20. doi: 10.4252/wjsc.v6.i4.404.
2
Stem cell transplantation.干细胞移植
West J Med. 1993 Sep;159(3):356-9.
3
Lymphocyte subpopulations in primary immunodeficiency disorders.原发性免疫缺陷病中的淋巴细胞亚群
Indian J Pediatr. 1982 May-Jun;49(398):399-408. doi: 10.1007/BF02834434.
4
Conception and development of the fetal tissue bank.胎儿组织库的构想与发展
J Clin Pathol. 1981 Mar;34(3):240-8. doi: 10.1136/jcp.34.3.240.
5
[Adenosine deaminase deficiency in primary immunodeficiencies (author's transl)].原发性免疫缺陷中的腺苷脱氨酶缺乏症（作者译）
Klin Wochenschr. 1976 Dec 1;54(23):1109-15. doi: 10.1007/BF01469254.
6
Extraneous HLA antigens in severe combined immunodeficiency disease (scid). Survey of the literature and report of one new case.重症联合免疫缺陷病（SCID）中的外来 HLA 抗原。文献综述及 1 例新病例报告。
Eur J Pediatr. 1977 Apr 26;125(1):39-43. doi: 10.1007/BF00470604.
7
Combined immunodeficiency and inborn errors of purine metabolism.联合免疫缺陷与嘌呤代谢先天性缺陷
Blut. 1978 Oct 13;37(4):173-81. doi: 10.1007/BF00996718.
8
Rationale for combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency.在重症联合免疫缺陷变异型患者中联合使用胎儿肝脏和胸腺进行免疫重建的理论依据。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3002-5. doi: 10.1073/pnas.74.7.3002.
9
Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.脱氧三磷酸腺苷作为腺苷脱氨酶缺乏症中一种潜在的有毒代谢物。
Proc Natl Acad Sci U S A. 1978 Jan;75(1):472-6. doi: 10.1073/pnas.75.1.472.
10
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).腺苷脱氨酶缺乏症和嘌呤核苷磷酸化酶缺乏症中的淋巴细胞特异性毒性：核苷激酶的可能作用。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5677-81. doi: 10.1073/pnas.74.12.5677.